Results of multivariate analyses comparing hematopoietic recovery and graft versus host disease after HLA-identical sibling blood stem cell transplantation and bone marrow transplantation
| Outcome . | Relative risk (95% CI) . | P value . |
|---|---|---|
| Absolute neutrophil count ≥ 0.5 × 109/L3-150,3-164 | 1.90 (1.58-2.28) | .0001 |
| Platelets > 20 × 109/L3-151,3-164 | 1.82 (1.52-2.17) | .0001 |
| Platelets > 50 × 109/L3-152,3-164 | 1.73 (1.43-2.09) | .0001 |
| Grades II-IV acute GVHD3-153,3-164 | 1.19 (0.91-1.56) | .20 |
| Chronic GVHD (limited or extensive)3-154,3-161 | 1.30 (1.00-1.70) | .05 |
| Chronic GVHD (extensive only)3-160,3-162 | 1.44 (1.02-2.01) | .04 |
| Outcome . | Relative risk (95% CI) . | P value . |
|---|---|---|
| Absolute neutrophil count ≥ 0.5 × 109/L3-150,3-164 | 1.90 (1.58-2.28) | .0001 |
| Platelets > 20 × 109/L3-151,3-164 | 1.82 (1.52-2.17) | .0001 |
| Platelets > 50 × 109/L3-152,3-164 | 1.73 (1.43-2.09) | .0001 |
| Grades II-IV acute GVHD3-153,3-164 | 1.19 (0.91-1.56) | .20 |
| Chronic GVHD (limited or extensive)3-154,3-161 | 1.30 (1.00-1.70) | .05 |
| Chronic GVHD (extensive only)3-160,3-162 | 1.44 (1.02-2.01) | .04 |
GVHD indicates graft versus host disease.
Model stratified on Karnofsky performance score, GVHD prophylaxis, and use of growth factor granulocyte colony-stimulating factor or granulocyte-macrophage colony-stimulating factor (G/GM-CSF); other significant variable was male sex (relative risk [RR], 0.80; P = .005).
Model stratified on GVHD prophylaxis; other significant variables were use of growth factor G/GM-CSF (RR, 0.79; P = .01) and Karnofsky performance score ≥ 90% (RR, 1.41; P = .002).
Model stratified on GVHD prophylaxis and use of growth factor G/GM-CSF; there were no other significant variables.
Model stratified on GVHD prophylaxis; there were no other significant variables.
Model stratified on sex and GVHD prophylaxis; other significant variable was age 40 years or older (RR, 1.36; P = .01).
Model stratified on sex and GVHD prophylaxis; there were no other significant variables.
No significant center effect was found.
Significant center effect was found; model adjusting for the influence of center showed higher risk of chronic GVHD for blood stem cell transplantation than for bone marrow transplantation (RR, 1.71; 95% confidence interval [CI], 1.08-2.71; P = .02).
Significant center effect was found; model adjusting for the influence of center showed higher risk of chronic GVHD for blood stem cell transplantation than for bone marrow transplantation (RR, 2.17; 95% CI, 1.13-4.18; P = .02).