Table 1.

Clinical characteristics of the study population

Characteristics Frequency n = 541 5 y OS 5 y DFS
LDH  
 ≤ Normal  43%  73 ± 6% 61 ± 6%  
 > Normal  57%  64 ± 5%* 56 ± 6%* 
Stage  
 Localized (I-II)  39% 76 ± 6%  66 ± 6%  
 Disseminated (III-IV) 61%  63 ± 5%* 51 ± 6%* 
Performance status  
 0-1  80%  70 ± 5%  59 ± 6% 
 2-4  20%  62 ± 8% 53 ± 9%  
IPI Score  
 0  15%  84 ± 8%  76 ± 10% 
 1  40%  70 ± 7%  58 ± 7%  
 2 35%  61 ± 8%  55 ± 8%  
 3 10%  58 ± 14%* 47 ± 14%* 
Consolidative treatment  
 Sequential chemotherapy  50.5%  67 ± 6% 54 ± 7%  
 HDT with ASCT  49.5%  69 ± 6% 62 ± 6% 
Characteristics Frequency n = 541 5 y OS 5 y DFS
LDH  
 ≤ Normal  43%  73 ± 6% 61 ± 6%  
 > Normal  57%  64 ± 5%* 56 ± 6%* 
Stage  
 Localized (I-II)  39% 76 ± 6%  66 ± 6%  
 Disseminated (III-IV) 61%  63 ± 5%* 51 ± 6%* 
Performance status  
 0-1  80%  70 ± 5%  59 ± 6% 
 2-4  20%  62 ± 8% 53 ± 9%  
IPI Score  
 0  15%  84 ± 8%  76 ± 10% 
 1  40%  70 ± 7%  58 ± 7%  
 2 35%  61 ± 8%  55 ± 8%  
 3 10%  58 ± 14%* 47 ± 14%* 
Consolidative treatment  
 Sequential chemotherapy  50.5%  67 ± 6% 54 ± 7%  
 HDT with ASCT  49.5%  69 ± 6% 62 ± 6% 

Log-rank test:

*

P < .01;

P < .05.

ASCT indicates autologous stem cell transplantation; DFS, disease-free survival; HDT, high-dose therapy; IPI, International Prognostic Index; LDH, lactate dehydrogenase; OS, overall survival.

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