Macroscopic analysis of TEL-JAK2 leukemic mice
| Animal no. . | Age . | WBC . | Spleen . | Thymus . | Lymph nodes . |
|---|---|---|---|---|---|
| 60T1 (control) | 6 | 1500 | 50 | 55 | − |
| 17 | 8 | ND | 1200 | ND | − |
| 30 | 10 | ND | 310 | ND | + |
| 43 | 8 | ND | 640 | ND | + |
| 60 | 6 | 9725 | 80 | 510 | + |
| 61 | 6 | ND | ND | ND | ND |
| 65 | 6 | 10 625 | 510 | 560 | − |
| 3-1-4 (control) | 10 | 2500 | 60 | 50 | − |
| 3-11 | 6 | ND | 150 | ND | + |
| 3-1-1 | 10 | ND | 240 | ND | − |
| 3-1-8 | 10 | 5650 | 160 | ND | − |
| 71-2 (control) | 8 | 2500 | 60 | 50 | − |
| 71-6 (control) | 8 | 2400 | 80 | 45 | − |
| 71-4 | 8 | 16 100 | 750 | 610 | + |
| 71-10 | 8 | 233 600 | 330 | 950 | + |
| 71-18 | 13 | 34 400 | 850 | 350 | − |
| 71-24 | 8 | 87 650 | 350 | 1210 | + |
| 71-43 | 22 | 8350 | 110 | 1000 | + |
| 71-45 | 9 | 31 650 | 650 | 360 | + |
| 71-3-7 | 19 | ND | 130 | 700 | + |
| 71-48-5 | 14 | ND | 280 | 330 | + |
| 71-18-1-3 | ND | 475 000 | 900 | 350 | + |
| 71-18-1-9 | ND | 18 000 | 380 | 360 | + |
| 71-4-8-2 | ND | 12 500 | 200 | 550 | + |
| Animal no. . | Age . | WBC . | Spleen . | Thymus . | Lymph nodes . |
|---|---|---|---|---|---|
| 60T1 (control) | 6 | 1500 | 50 | 55 | − |
| 17 | 8 | ND | 1200 | ND | − |
| 30 | 10 | ND | 310 | ND | + |
| 43 | 8 | ND | 640 | ND | + |
| 60 | 6 | 9725 | 80 | 510 | + |
| 61 | 6 | ND | ND | ND | ND |
| 65 | 6 | 10 625 | 510 | 560 | − |
| 3-1-4 (control) | 10 | 2500 | 60 | 50 | − |
| 3-11 | 6 | ND | 150 | ND | + |
| 3-1-1 | 10 | ND | 240 | ND | − |
| 3-1-8 | 10 | 5650 | 160 | ND | − |
| 71-2 (control) | 8 | 2500 | 60 | 50 | − |
| 71-6 (control) | 8 | 2400 | 80 | 45 | − |
| 71-4 | 8 | 16 100 | 750 | 610 | + |
| 71-10 | 8 | 233 600 | 330 | 950 | + |
| 71-18 | 13 | 34 400 | 850 | 350 | − |
| 71-24 | 8 | 87 650 | 350 | 1210 | + |
| 71-43 | 22 | 8350 | 110 | 1000 | + |
| 71-45 | 9 | 31 650 | 650 | 360 | + |
| 71-3-7 | 19 | ND | 130 | 700 | + |
| 71-48-5 | 14 | ND | 280 | 330 | + |
| 71-18-1-3 | ND | 475 000 | 900 | 350 | + |
| 71-18-1-9 | ND | 18 000 | 380 | 360 | + |
| 71-4-8-2 | ND | 12 500 | 200 | 550 | + |
Three groups are described. Transgenic animals 17, 30, 43, 60, 61, and 65 are founder mice that died before breeding. Animals 3-11, 3-1-1, and 3-1-8 are F1 and F2 progeny-derived transgenic mouse 3 obtained from backcrosses to C57B6. Animals derived from founder mouse 71 include F1, F2, and F3 progeny obtained from backcrosses to C57B6. Age-matched nontransgenic littermate controls are indicated in italics.
Age indicates age at death or sacrifice in weeks; WBC indicates white blood cell count per microliter; for spleen, thymus, and lymph nodes, weight is expressed in milligrams; ND indicates no data.