Table 1. Mutational analysis of... | American Society of Hematology

Table 1.

Mutational analysis of consensus salivary gland lymphomaV_H genes

Case no.	GermlineV_H gene	% homology	CDR1 and 2				FW1, 2, and 3
Case no.	GermlineV_H gene	% homology	R	S	R/S	Random R/S	R	S	R/S	Random R/S
1	V1-69	97	4	0	4	3.6	3	1	3	3
2	V1-69	91	6	5	1.2	3.6	5	11	0.45	3
3	V1-69	98	1	0	1	3.6	2	3	0.67	3
4	V1-69	92	6	4	1.5	3.6	7	7	1	3
5	V1-69	93	2	5	0.4	3.6	7	8	0.87	3
6	V1-69	98	3	0	3	3.6	1	2	0.5	3
7	V1-69	98	1	3	0.3	3.6	2	1	2	3
8	V1-69	97	1	2	0.5	3.6	4	2	2	3
9	V1-46	94	6	3	2	4.2	1	7	0.14	2.8
10	V3-7	98	2	0	2	4.9	1	2	0.5	2.8
11	V3-30.3	100
12	V3-11	94	3	1	3	4.3	6	8	0.75	2.8
13	V3-30	91	5	4	1.2	3.9	10	7	1.4	2.8
14	V4-39	94	4	1	4	4.5	7	4	1.7	2.6

Case no.	GermlineV_H gene	% homology	CDR1 and 2				FW1, 2, and 3
Case no.	GermlineV_H gene	% homology	R	S	R/S	Random R/S	R	S	R/S	Random R/S
1	V1-69	97	4	0	4	3.6	3	1	3	3
2	V1-69	91	6	5	1.2	3.6	5	11	0.45	3
3	V1-69	98	1	0	1	3.6	2	3	0.67	3
4	V1-69	92	6	4	1.5	3.6	7	7	1	3
5	V1-69	93	2	5	0.4	3.6	7	8	0.87	3
6	V1-69	98	3	0	3	3.6	1	2	0.5	3
7	V1-69	98	1	3	0.3	3.6	2	1	2	3
8	V1-69	97	1	2	0.5	3.6	4	2	2	3
9	V1-46	94	6	3	2	4.2	1	7	0.14	2.8
10	V3-7	98	2	0	2	4.9	1	2	0.5	2.8
11	V3-30.3	100
12	V3-11	94	3	1	3	4.3	6	8	0.75	2.8
13	V3-30	91	5	4	1.2	3.9	10	7	1.4	2.8
14	V4-39	94	4	1	4	4.5	7	4	1.7	2.6

Columns headed with “R” or “S” give the number of deduced replacement or silent mutations from the proposed germlineV_H nucleotide sequences, respectively. “Random R/S” refers to the ratio of all possible replacement to silent mutations for the given areas as described by Chang and Casali.31

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