Treatment of disseminated Hodgkin lymphoma in SCID mice with rIT4-150
| . | PBS . | ETA′ . | Ki-4(scFv)–ETA′ . |
|---|---|---|---|
| No. mice | 10 | 5 | 10 |
| L540rec tumors in | |||
| Superficial cervical LN | 5 | 2 | 0 |
| Posterior cervical LN | 1 | 2 | 0 |
| Facial LN | 5 | 1 | 0 |
| Iliac LN | 3 | 1 | 0 |
| Bone marrow | 1 | 0 | 0 |
| Brain | 10 | 5 | 1 |
| Muscle | 6 | 2 | 0 |
| Kidney | 2 | 2 | 0 |
| Ovary | 0 | 3 | 0 |
| Thymus | 2 | 3 | 0 |
| MST | 38.1 ± 1.77 | 39.8 ± 2.56 | 201.6 ± 17.46 |
| No. CR (%) | — | — | 9 (90%) |
| Significance (rel. to PBS) | — | P = .58 | P < .001 |
| . | PBS . | ETA′ . | Ki-4(scFv)–ETA′ . |
|---|---|---|---|
| No. mice | 10 | 5 | 10 |
| L540rec tumors in | |||
| Superficial cervical LN | 5 | 2 | 0 |
| Posterior cervical LN | 1 | 2 | 0 |
| Facial LN | 5 | 1 | 0 |
| Iliac LN | 3 | 1 | 0 |
| Bone marrow | 1 | 0 | 0 |
| Brain | 10 | 5 | 1 |
| Muscle | 6 | 2 | 0 |
| Kidney | 2 | 2 | 0 |
| Ovary | 0 | 3 | 0 |
| Thymus | 2 | 3 | 0 |
| MST | 38.1 ± 1.77 | 39.8 ± 2.56 | 201.6 ± 17.46 |
| No. CR (%) | — | — | 9 (90%) |
| Significance (rel. to PBS) | — | P = .58 | P < .001 |
Animals received a singular intravenous injection of 40 μg ETA′ or Ki-4(scFv)–ETA′ in PBS or PBS on day 1 after L540rec inoculation.