Data from untreated and treated β-thalessmic mice followed for 10-12 months and investigated at time of sacrifice
| . | Untreated . | Treated, Nos. . | ||||||
|---|---|---|---|---|---|---|---|---|
| +/− . | −/− . | 1 . | 2 . | 3 . | 4 . | 7 . | 8 . | |
| Index value of the amount of transduced muscle | 0 | 0 | 6.6 | 10 | 12 | 16.8 | 23.4 | 18 |
| Mean serum Epo concentration, mU/mL* | 39.2 ± 8.4 | 150 ± 37 | 265 ± 69 | 274 ± 57 | 352 ± 40 | 498 ± 77 | 617 ± 17 | 1279 ± 92 |
| Mean Hct, %* | 45.6 | 29.7 | 44.7 | 48 | 62.6 | 58.4 | 69.8 | 75.4 |
| Mean Hb, g/dL* | 15.6 | 8.6 | 13 | 13.4 | 17.3 | 16.2 | 19.9 | 22 |
| Mean corpuscular Hb content, pg/dL* | 34 | 29 | 29 | 28 | 27.8 | 27.7 | 28 | 29 |
| Mean RBC count, ×109 cells/dl* | 10 | 9.3 | 11.6 | 13 | 15 | 15 | >16 | >16 |
| Mean globular volume, fL* | 45 | 32 | 38 | 37 | 41.7 | 36 | — | — |
| Mean corpuscular Hb, pg/cell* | 15 | 9 | 11.2 | 10 | 11.5 | 10.8 | — | — |
| β-minor/α-chain in blood, % | 0.21 ± 0.03 | 0.67 | 0.85 | 0.87 | 0.91 | 0.84 | 0.84 | 0.99 |
| α-chain content in erythrocyte membrane, % of −/− | 5 ± 2 | 100 | 60 | 55 | 47.5 | 56 | 52.4 | 32.8 |
| Spleen weight, mg | 96 ± 3.6 | 577 ± 36 | 582 | 520 | 892 | 850 | 952 | 941 |
| 59Fe half-life in serum, min | 46 ± 6.1 | 21 ± 2.8 | 37 | 33 | 19 | 19 | 14 | 10 |
| . | Untreated . | Treated, Nos. . | ||||||
|---|---|---|---|---|---|---|---|---|
| +/− . | −/− . | 1 . | 2 . | 3 . | 4 . | 7 . | 8 . | |
| Index value of the amount of transduced muscle | 0 | 0 | 6.6 | 10 | 12 | 16.8 | 23.4 | 18 |
| Mean serum Epo concentration, mU/mL* | 39.2 ± 8.4 | 150 ± 37 | 265 ± 69 | 274 ± 57 | 352 ± 40 | 498 ± 77 | 617 ± 17 | 1279 ± 92 |
| Mean Hct, %* | 45.6 | 29.7 | 44.7 | 48 | 62.6 | 58.4 | 69.8 | 75.4 |
| Mean Hb, g/dL* | 15.6 | 8.6 | 13 | 13.4 | 17.3 | 16.2 | 19.9 | 22 |
| Mean corpuscular Hb content, pg/dL* | 34 | 29 | 29 | 28 | 27.8 | 27.7 | 28 | 29 |
| Mean RBC count, ×109 cells/dl* | 10 | 9.3 | 11.6 | 13 | 15 | 15 | >16 | >16 |
| Mean globular volume, fL* | 45 | 32 | 38 | 37 | 41.7 | 36 | — | — |
| Mean corpuscular Hb, pg/cell* | 15 | 9 | 11.2 | 10 | 11.5 | 10.8 | — | — |
| β-minor/α-chain in blood, % | 0.21 ± 0.03 | 0.67 | 0.85 | 0.87 | 0.91 | 0.84 | 0.84 | 0.99 |
| α-chain content in erythrocyte membrane, % of −/− | 5 ± 2 | 100 | 60 | 55 | 47.5 | 56 | 52.4 | 32.8 |
| Spleen weight, mg | 96 ± 3.6 | 577 ± 36 | 582 | 520 | 892 | 850 | 952 | 941 |
| 59Fe half-life in serum, min | 46 ± 6.1 | 21 ± 2.8 | 37 | 33 | 19 | 19 | 14 | 10 |
The mean ± SEM of measures performed in at least 3 untreated control animals.
Indicates that the mean ± SEM of these values were collected over the last 6 months of life. SEMs less than 5% of the value are not shown.