Table 5. Antigen density and Rhesus D... | American Society of Hematology

Table 5.

Antigen density and Rhesus D similarity index

RhD Phenotype	Antigen Density	Rhesus D Similarity Index	Percentiles of RhD Epitopes Detected			Antibodies
RhD Phenotype	Antigen Density	Rhesus D Similarity Index	10%	50%	90%	Tested	>Cutoff^5-150
Controls
CcDee	13 283	0.90	12 534	13 238	13 986	59	59
CcDEe	24 509	0.84	21 982	24 509	26 322	59	59
CCDee	22 778	0.84	20 124	22 778	24 079	59	59
ccDEe	19 710	0.87	18 120	19 710	20 803	59	59
ccDee	23 240	0.88	21 884	23 240	24 984	59	59
Partial D types
D^IIIc	26 889	0.69	23 654	26 889	34 085	59	59
D^III type IV	33 255	0.45	17 200	33 255	38 515	59	59
D^IV type III^5-151	607	0	0	46	1 552	59	17
D^VI type I	1 050	0	0	0	1 279	59^5-152	14
D^VI type II	2 886	0	0	0	3 303	59^5-152	18
D^VI type III	14 502	0	0	0	17 674	59^5-152	17
D^VII	8 398	0.48	4 788	8 394	9 936	59	58
DHMi	2 292	0.12	413	2 200	3 465	59	54
DIM	192	0	0	0	245	59	20
Weak D types
Type 1	1 285	0.57	823	1 285	1 454	59	59
Type 2	489	0.68	378	489	555	59	59
Type 3	1 932	0.77	1 597	1 932	2 081	59	59
Type 4.0	2 288	0.36	977	2 288	2 707	59	59
Type 4.1	3 811	0.48	2 140	3 811	4 453	59	59
Type 4.2	1 650	0.21	456	1 650	2 121	58	58
Type 5	296	0.39	137	295	355	59	57
Type 6	1 053	0.79	857	1 053	1 088	5	5
Type 7	2 409	0.03	105	1 950	3 450	59	44
Type 8	972	0.75	824	972	1 105	59	59
Type 9	248	0.43	135	248	312	59	59
Type 10^5-153	1 186	0.34	867	1 186	2 579	58	58
Type 11	183	0.53	127	183	238	59	59
Type 12	96	nc^5-154	0	76	153	41	30
Type 13	946	0.33	375	946	1 124	59	59
Type 15	297	0.21	92	297	435	59	58
Type 16	235	0.44	151	234	346	55	54
Type 17	66	nc	40	63	176	59	58

RhD Phenotype	Antigen Density	Rhesus D Similarity Index	Percentiles of RhD Epitopes Detected			Antibodies
RhD Phenotype	Antigen Density	Rhesus D Similarity Index	10%	50%	90%	Tested	>Cutoff^5-150
Controls
CcDee	13 283	0.90	12 534	13 238	13 986	59	59
CcDEe	24 509	0.84	21 982	24 509	26 322	59	59
CCDee	22 778	0.84	20 124	22 778	24 079	59	59
ccDEe	19 710	0.87	18 120	19 710	20 803	59	59
ccDee	23 240	0.88	21 884	23 240	24 984	59	59
Partial D types
D^IIIc	26 889	0.69	23 654	26 889	34 085	59	59
D^III type IV	33 255	0.45	17 200	33 255	38 515	59	59
D^IV type III^5-151	607	0	0	46	1 552	59	17
D^VI type I	1 050	0	0	0	1 279	59^5-152	14
D^VI type II	2 886	0	0	0	3 303	59^5-152	18
D^VI type III	14 502	0	0	0	17 674	59^5-152	17
D^VII	8 398	0.48	4 788	8 394	9 936	59	58
DHMi	2 292	0.12	413	2 200	3 465	59	54
DIM	192	0	0	0	245	59	20
Weak D types
Type 1	1 285	0.57	823	1 285	1 454	59	59
Type 2	489	0.68	378	489	555	59	59
Type 3	1 932	0.77	1 597	1 932	2 081	59	59
Type 4.0	2 288	0.36	977	2 288	2 707	59	59
Type 4.1	3 811	0.48	2 140	3 811	4 453	59	59
Type 4.2	1 650	0.21	456	1 650	2 121	58	58
Type 5	296	0.39	137	295	355	59	57
Type 6	1 053	0.79	857	1 053	1 088	5	5
Type 7	2 409	0.03	105	1 950	3 450	59	44
Type 8	972	0.75	824	972	1 105	59	59
Type 9	248	0.43	135	248	312	59	59
Type 10^5-153	1 186	0.34	867	1 186	2 579	58	58
Type 11	183	0.53	127	183	238	59	59
Type 12	96	nc^5-154	0	76	153	41	30
Type 13	946	0.33	375	946	1 124	59	59
Type 15	297	0.21	92	297	435	59	58
Type 16	235	0.44	151	234	346	55	54
Type 17	66	nc	40	63	176	59	58

F5-150

Number of monoclonal anti-D detecting at least 0.1 of the 90% percentile of the epitope density detected by all anti-D.

F5-151

Single sample of CCDee phenotype; the antigen density may be depressed by the presence of Cde in trans.

F5-152

Results derived from a reanalysis of published data.18Thirty-nine of the 59 antibodies used in this study were known to be nonreactive to D^VI, and their results were assumed to be 0.

F5-153

Result of the positive subpopulation (see “Materials and methods”); analysis including nonstaining cells resulted in antigen density 157; D similarity index, 0.39.

F5-154

nc, not calculated, because 90 percentile was less than 200 antigens per cell.

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