Reactivity patterns of antibodies with new partial and weak D
Pattern* . | Antibodies† . | Partial D‡ . | Weak D Type . | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-9 . | 1-37 . | IgG . | IgM . | DIII . | DIV . | DIM . | 1 . | 2 . | 3 . | 4.0 . | 4.1 . | 4.2 . | 5 . | 7 . | 8 . | 9 . | 10 . | 11 . | 12 . | 13 . | 15 . | 16 . | 17 . |
1 | 1 | 82 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
1 | 2 | 79 | + | − | − | + | + | + | + | + | w | w | + | + | − | + | w | − | w | − | − | − | |
83 | + | − | − | w | w | + | + | + | − | w | + | + | − | + | w | − | + | − | − | − | |||
2 | 3 | 44 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
51 | + | − | − | + | + | + | + | + | + | + | + | + | w | + | − | − | + | − | w | − | |||
2 | 4 | 48 | + | − | − | − | − | w | + | + | − | − | − | w | − | + | − | − | − | − | − | − | |
3 | 5 | 75 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
43, 49 | + | − | +w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
4 | 6 | 45 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
5 | 7 | 116 | w | + | − | w | w | + | + | + | − | w | + | + | − | + | w | − | w | − | − | − | |
42 | + | + | − | w | w | + | + | + | + | − | w | w | − | + | − | − | w | − | − | − | |||
5 | 10 | 88, 89 | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | w | + | w | |
41 | + | + | − | + | w | + | + | + | + | w | w | + | − | + | − | − | + | − | w | − | |||
52 | + | w | − | − | − | w | w | + | w | − | − | w | − | w | − | − | − | − | − | − | |||
5 | 11 | 69 | + | + | − | − | − | w | w | w | − | − | + | − | − | + | − | − | − | − | − | − | |
6/7 | 12 | 102 | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
46 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | w | − | |||
113 | + | + | − | w | w | + | + | + | + | w | + | + | − | + | w | − | w | − | w | − | |||
35 | + | + | − | w | w | + | + | + | + | − | + | w | − | + | − | − | w | − | − | − | |||
6/7 | 13 | 29, 36, 47, 90, 93, 105 | +w | + | +w | + | +w | + | + | + | + | + | + | + | + | + | + | +w | + | +w | + | w | |
6/7 | 15/16 | 71, 81, 97 | + | + | +w | + | + | + | + | + | +w | + | + | + | + | + | + | w | + | + | + | w | |
32, 58, 108, 114 | + | + | w | + | + | + | + | +w | + | + | + | + | + | + | + | w | + | +w | + | − | |||
56 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
31, 95 | +w | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |||
59 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
80 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | w | − | |||
6/7 | 17 | 134 | + | w | − | w | w | w | w | − | − | w | + | + | w | + | w | − | w | − | − | − | |
115 | w | + | − | w | w | w | w | w | − | w | + | + | − | + | w | − | w | − | − | − | |||
99 | + | + | − | w | w | + | + | + | w | w | + | + | − | + | w | − | − | − | − | − | |||
98 | w | + | − | w | w | + | + | + | − | w | + | + | − | + | w | − | − | − | − | − | |||
28, 34 | + | + | − | w | − | + | + | + | + | − | + | +w | − | + | − | − | w | − | − | − | |||
37 | + | + | − | w | w | + | + | + | + | − | + | w | − | + | − | − | w | − | − | − | |||
39 | + | w | − | − | − | + | + | + | − | − | − | + | − | + | − | − | − | − | − | − | |||
6/7 | 18 | 30 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | − | + | − | |
119 | + | + | − | + | + | + | + | + | + | w | + | + | w | + | w | − | + | − | − | − | |||
84, 85 | + | + | − | w | w | + | + | + | w | w | + | + | − | + | w | − | w | − | − | − | |||
86, 87 | w | w | − | w | w | +w | w | w | − | w | +w | w | − | + | w | − | − | − | − | − | |||
100 | w | w | − | w | w | w | w | − | − | w | + | + | − | + | w | − | − | − | − | − | |||
6/7 | 20/21 | 33 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | w | + | − | |
94 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | w | − | |||
122 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | + | − | |||
61 | + | − | − | w | w | + | w | w | − | − | − | + | − | w | − | − | w | − | − | − | |||
8 | 22 | 74, 78 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | +w | − | |
9 | 23 | 112 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
101, 118 | +w | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | +w | + | − | |||
120, 121 | + | − | + | + | + | + | + | +w | + | + | + | + | + | + | + | − | + | +w | + | − | |||
96 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | − | |||
77 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
N/A | 31 | 54, 57 | +w | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | |
N/A | 32 | 62 | + | + | − | w | w | + | w | w | − | − | − | w | − | + | − | − | w | − | − | − | |
N/A | 33 | 38 | + | w | − | − | − | + | + | + | − | − | − | + | − | w | − | − | − | − | − | − | |
N/A | 34 | 50 | + | − | − | w | + | + | + | w | − | − | − | w | − | w | − | − | w | − | − | − | |
N/A | 35 | 60 | + | − | − | + | + | + | + | + | + | w | + | + | w | + | − | − | + | − | w | − | |
N/A | 36 | 72, 76 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
55 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
53 | + | − | − | + | + | + | + | + | + | + | w | + | − | + | w | − | + | − | + | − | |||
N/A | 37 | 68, 73, 117, 124, 180 | + | + | +w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | +w | + | +w |
Pattern* . | Antibodies† . | Partial D‡ . | Weak D Type . | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-9 . | 1-37 . | IgG . | IgM . | DIII . | DIV . | DIM . | 1 . | 2 . | 3 . | 4.0 . | 4.1 . | 4.2 . | 5 . | 7 . | 8 . | 9 . | 10 . | 11 . | 12 . | 13 . | 15 . | 16 . | 17 . |
1 | 1 | 82 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
1 | 2 | 79 | + | − | − | + | + | + | + | + | w | w | + | + | − | + | w | − | w | − | − | − | |
83 | + | − | − | w | w | + | + | + | − | w | + | + | − | + | w | − | + | − | − | − | |||
2 | 3 | 44 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
51 | + | − | − | + | + | + | + | + | + | + | + | + | w | + | − | − | + | − | w | − | |||
2 | 4 | 48 | + | − | − | − | − | w | + | + | − | − | − | w | − | + | − | − | − | − | − | − | |
3 | 5 | 75 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
43, 49 | + | − | +w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
4 | 6 | 45 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
5 | 7 | 116 | w | + | − | w | w | + | + | + | − | w | + | + | − | + | w | − | w | − | − | − | |
42 | + | + | − | w | w | + | + | + | + | − | w | w | − | + | − | − | w | − | − | − | |||
5 | 10 | 88, 89 | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | w | + | w | |
41 | + | + | − | + | w | + | + | + | + | w | w | + | − | + | − | − | + | − | w | − | |||
52 | + | w | − | − | − | w | w | + | w | − | − | w | − | w | − | − | − | − | − | − | |||
5 | 11 | 69 | + | + | − | − | − | w | w | w | − | − | + | − | − | + | − | − | − | − | − | − | |
6/7 | 12 | 102 | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |
46 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | w | − | |||
113 | + | + | − | w | w | + | + | + | + | w | + | + | − | + | w | − | w | − | w | − | |||
35 | + | + | − | w | w | + | + | + | + | − | + | w | − | + | − | − | w | − | − | − | |||
6/7 | 13 | 29, 36, 47, 90, 93, 105 | +w | + | +w | + | +w | + | + | + | + | + | + | + | + | + | + | +w | + | +w | + | w | |
6/7 | 15/16 | 71, 81, 97 | + | + | +w | + | + | + | + | + | +w | + | + | + | + | + | + | w | + | + | + | w | |
32, 58, 108, 114 | + | + | w | + | + | + | + | +w | + | + | + | + | + | + | + | w | + | +w | + | − | |||
56 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
31, 95 | +w | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |||
59 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
80 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | w | − | |||
6/7 | 17 | 134 | + | w | − | w | w | w | w | − | − | w | + | + | w | + | w | − | w | − | − | − | |
115 | w | + | − | w | w | w | w | w | − | w | + | + | − | + | w | − | w | − | − | − | |||
99 | + | + | − | w | w | + | + | + | w | w | + | + | − | + | w | − | − | − | − | − | |||
98 | w | + | − | w | w | + | + | + | − | w | + | + | − | + | w | − | − | − | − | − | |||
28, 34 | + | + | − | w | − | + | + | + | + | − | + | +w | − | + | − | − | w | − | − | − | |||
37 | + | + | − | w | w | + | + | + | + | − | + | w | − | + | − | − | w | − | − | − | |||
39 | + | w | − | − | − | + | + | + | − | − | − | + | − | + | − | − | − | − | − | − | |||
6/7 | 18 | 30 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | − | + | − | |
119 | + | + | − | + | + | + | + | + | + | w | + | + | w | + | w | − | + | − | − | − | |||
84, 85 | + | + | − | w | w | + | + | + | w | w | + | + | − | + | w | − | w | − | − | − | |||
86, 87 | w | w | − | w | w | +w | w | w | − | w | +w | w | − | + | w | − | − | − | − | − | |||
100 | w | w | − | w | w | w | w | − | − | w | + | + | − | + | w | − | − | − | − | − | |||
6/7 | 20/21 | 33 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | w | + | w | + | − | |
94 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | w | − | |||
122 | + | + | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | + | − | |||
61 | + | − | − | w | w | + | w | w | − | − | − | + | − | w | − | − | w | − | − | − | |||
8 | 22 | 74, 78 | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | − | +w | − | |
9 | 23 | 112 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
101, 118 | +w | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | +w | + | − | |||
120, 121 | + | − | + | + | + | + | + | +w | + | + | + | + | + | + | + | − | + | +w | + | − | |||
96 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | − | |||
77 | + | − | w | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
N/A | 31 | 54, 57 | +w | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | |
N/A | 32 | 62 | + | + | − | w | w | + | w | w | − | − | − | w | − | + | − | − | w | − | − | − | |
N/A | 33 | 38 | + | w | − | − | − | + | + | + | − | − | − | + | − | w | − | − | − | − | − | − | |
N/A | 34 | 50 | + | − | − | w | + | + | + | w | − | − | − | w | − | w | − | − | w | − | − | − | |
N/A | 35 | 60 | + | − | − | + | + | + | + | + | + | w | + | + | w | + | − | − | + | − | w | − | |
N/A | 36 | 72, 76 | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | w | + | + | + | w | |
55 | + | − | − | + | + | + | + | + | + | + | + | + | + | + | + | − | + | w | + | − | |||
53 | + | − | − | + | + | + | + | + | + | + | w | + | − | + | w | − | + | − | + | − | |||
N/A | 37 | 68, 73, 117, 124, 180 | + | + | +w | + | + | + | + | + | + | + | + | + | + | + | + | w | + | +w | + | +w |
Pattern as described previously by Lomas et al14(1-9) and Scott16 (1-37), who did not differentiate epitopes 15 from 16 and epitopes 20 from 21 (Table1 16).
Antibody numbers as defined in “Materials and methods” section. Reactivity was tested in a gel matrix test. + indicates a normal positive result; “w,” a weak positive result; +w, either + or w, depending on the antibody; and −, a negative result.
DIII, D category III type IV described in this study; DIV, D category IV type III described previously.26