Table 1.

Prognostic significance of factors at CLL diagnosis related to the occurrence of DAT-negative and DAT-positive anemia: univariate and multivariate analysis

Factors at CLL diagnosisDAT-Negative Anemia*DAT-Positive Anemia
UnivariateMultivariate UnivariateMultivariate
N % with neg. DAT anemiaP value P value Odds ratio (95% CI) N % with pos. DAT anemia P valueP value Odds ratio (95% CI)
Age (y) 
 ≤ 65  692  7.2     650  1.2  
 > 65 492  9.5  .15  .04  1.58  456  2.4  .14 .01  3.18 
     (1.02-2.45)     (1.19-8.52)  
Sex  
 M  718  7.9    678  2.5  
 F  466  8.5  .69  .4 —  428  0.4  .01  .01  0.16 
          (0.03-0.73) 
Lymph × 109/L  
 ≤ 60  1072  5.7    1016  0.5  
 > 60  112  31.0 < .00001  < .00001  17.84  90  14.0 < .00001  < .00001  22.7 
     (4.84-12.7)     (8.23-62.6) 
Factors at CLL diagnosisDAT-Negative Anemia*DAT-Positive Anemia
UnivariateMultivariate UnivariateMultivariate
N % with neg. DAT anemiaP value P value Odds ratio (95% CI) N % with pos. DAT anemia P valueP value Odds ratio (95% CI)
Age (y) 
 ≤ 65  692  7.2     650  1.2  
 > 65 492  9.5  .15  .04  1.58  456  2.4  .14 .01  3.18 
     (1.02-2.45)     (1.19-8.52)  
Sex  
 M  718  7.9    678  2.5  
 F  466  8.5  .69  .4 —  428  0.4  .01  .01  0.16 
          (0.03-0.73) 
Lymph × 109/L  
 ≤ 60  1072  5.7    1016  0.5  
 > 60  112  31.0 < .00001  < .00001  17.84  90  14.0 < .00001  < .00001  22.7 
     (4.84-12.7)     (8.23-62.6) 
*

Patients with DAT-positive anemia (AHA) at CLL diagnosis excluded (19 patients).

Patients with DAT-negative anemia at CLL diagnosis excluded (97 patients).