Summary of nucleotide changes identified in the CLL samples*
| AA Position . | Substitution . | AA Change . | CD79b . | CLL Samples† . |
|---|---|---|---|---|
| 16 | GCT → GCG | ala → ala | Leader | 1, 2, 3, 4, 5, 6, 7, 8, 9 |
| 23 | GCA insertion | ala insertion | Leader | 2, 3, 4, 5, 6, 7, 9 |
| 34 | CGG → CAG | arg → gln | Connecting peptide | 4 |
| 54 | GCC → CCC | ala → pro | Ig domain | 8 |
| 58 | GCC → GGC | ala → gly | Ig domain | 1, 2, 3, 4, 5, 6, 7, 8 |
| 73 | AAT → TAT | asn → tyr | Ig domain | 8 |
| 75 | AGC → ACC | ser → thr | Ig domain | 8 |
| 81 | GAG → GAT | glu → asp | Ig domain | 2 |
| 84 | GCG → GAG | ala → glu | Ig domain | 4, 5, 6, 7 |
| 100 | CAG → CAT | gln → his | Ig domain | 3 |
| 102 | GAA → GAT | glu → asp | Ig domain | 3 |
| 122 | TGT → TGC | cys → cys | Ig domain | 1, 2, 7, 9 |
| AA Position . | Substitution . | AA Change . | CD79b . | CLL Samples† . |
|---|---|---|---|---|
| 16 | GCT → GCG | ala → ala | Leader | 1, 2, 3, 4, 5, 6, 7, 8, 9 |
| 23 | GCA insertion | ala insertion | Leader | 2, 3, 4, 5, 6, 7, 9 |
| 34 | CGG → CAG | arg → gln | Connecting peptide | 4 |
| 54 | GCC → CCC | ala → pro | Ig domain | 8 |
| 58 | GCC → GGC | ala → gly | Ig domain | 1, 2, 3, 4, 5, 6, 7, 8 |
| 73 | AAT → TAT | asn → tyr | Ig domain | 8 |
| 75 | AGC → ACC | ser → thr | Ig domain | 8 |
| 81 | GAG → GAT | glu → asp | Ig domain | 2 |
| 84 | GCG → GAG | ala → glu | Ig domain | 4, 5, 6, 7 |
| 100 | CAG → CAT | gln → his | Ig domain | 3 |
| 102 | GAA → GAT | glu → asp | Ig domain | 3 |
| 122 | TGT → TGC | cys → cys | Ig domain | 1, 2, 7, 9 |
The numbering of the amino acid (AA) sequences of the CD79b molecule begins with the ATG methionine start codon. The leader peptide is from AA position 1 to 25, the connecting peptide is from AA 26 to 40, the immunoglobulin-like domain is between AA position 41 to 144, the second connecting peptide is between AA position 145 and 160, the transmembrane domain is between AA position 161 and 182, the cytoplasmic domain is between AA position 183 and 229. Ala = alanine; arg = arginine; asn = asparagine; asp = aspartic acid; CLL = chronic lymphocytic leukemia; cys = cysteine; gln = glutamine; glu = glutamic acid; gly = glycine; his = histidine; Ig = immunoglobulin; pro = proline; ser = serine; thr = threonine; try = tyrosine.
CLL samples 1, 2, 3, 4, and 5 express only one immunoglobulin heavy-chain allele; CLL samples 6, 7, 8, and 9 express both immunoglobulin heavy-chain alleles.