Thrombotic risk according to the presence or absence of a PROS1 gene defect and other prothrombotic defects*
| . | PROS1 gene abnormal (n = 57) . | PROS1 gene normal (n = 52) . | ||
|---|---|---|---|---|
| Without other defect (n = 51) . | With other defect (n = 6) . | Without other defect (n = 45) . | With other defect (n = 7) . | |
| Male, n (%) | 19 (37.2) | 2 (33.3) | 21 (46.6) | 4 (57.2) |
| No. (%) with thrombosis | 21 (41.2) | 2 (33.3) | 3 (6.6) | 1 (14.2) |
| Total thrombotic events | 41 | 3 | 4 | 1 |
| Years of follow-up | 2381 | 288 | 1713 | 287 |
| Age at first thrombosis, median (range) | 34.8 (17.1-69.5) | 35.1 | 24.5 (20.4-35.7) | 52.2 |
| Events per 1000 person-years, median (range) | 17.2 (12.3-23.4) | 10.4 (2.2-30.5) | 2.3 (0.6-6.0) | 3.4 (0.1-19.4) |
| Relative risk for thrombosis (95% CI) | 5.0 (1.5-16.8) | 4.0 (0.7-23.7) | 1 | 2.0 (0.2-19.1) |
| . | PROS1 gene abnormal (n = 57) . | PROS1 gene normal (n = 52) . | ||
|---|---|---|---|---|
| Without other defect (n = 51) . | With other defect (n = 6) . | Without other defect (n = 45) . | With other defect (n = 7) . | |
| Male, n (%) | 19 (37.2) | 2 (33.3) | 21 (46.6) | 4 (57.2) |
| No. (%) with thrombosis | 21 (41.2) | 2 (33.3) | 3 (6.6) | 1 (14.2) |
| Total thrombotic events | 41 | 3 | 4 | 1 |
| Years of follow-up | 2381 | 288 | 1713 | 287 |
| Age at first thrombosis, median (range) | 34.8 (17.1-69.5) | 35.1 | 24.5 (20.4-35.7) | 52.2 |
| Events per 1000 person-years, median (range) | 17.2 (12.3-23.4) | 10.4 (2.2-30.5) | 2.3 (0.6-6.0) | 3.4 (0.1-19.4) |
| Relative risk for thrombosis (95% CI) | 5.0 (1.5-16.8) | 4.0 (0.7-23.7) | 1 | 2.0 (0.2-19.1) |
Other inherited prothrombotic defects include antithrombin deficiency, factor V Leiden, or prothrombin 20 210A allele.