Genetic abnormalities in ALK-positive lymphoma that create fusion genes
| Chromosomal Anomaly . | ALK Partner . | M wt of ALK-Hybrid . | Immunostaining Pattern for ALK . |
|---|---|---|---|
| t(2;5)(p23;q35) | NPM7 | 80 | Nuclear, diffuse cytoplasmic |
| t(1;2)(q25;p23) | TPM314 | 104 | Diffuse cytoplasmic with peripheral intensification |
| t(2;3)(p23;q21) | TFG17 | 97 | Diffuse cytoplasmic |
| Inv (2)(p23q35) | ATIC* | 96 | Diffuse cytoplasmic |
| Chromosomal Anomaly . | ALK Partner . | M wt of ALK-Hybrid . | Immunostaining Pattern for ALK . |
|---|---|---|---|
| t(2;5)(p23;q35) | NPM7 | 80 | Nuclear, diffuse cytoplasmic |
| t(1;2)(q25;p23) | TPM314 | 104 | Diffuse cytoplasmic with peripheral intensification |
| t(2;3)(p23;q21) | TFG17 | 97 | Diffuse cytoplasmic |
| Inv (2)(p23q35) | ATIC* | 96 | Diffuse cytoplasmic |
Own unpublished results (ATIC: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).
M wt indicates molecular weight.