Table 2.

Summary of mutations recurrently affecting the same nucleotide in the 5′ regulatory region of the BCL-6 gene

Position Mutation Number of Reported MutationsReference
84  G → A  2  15, 26  
 G → C 1  26  
 G → T  1  27  
122  G → C  29  
 G → A* 3  26, 27  
123  C → T  Present study, 15, 26  
 C → G  2  15, 26  
186 T → C  3  Present study, 26  
190  T → C  Present study  
 T → A  2  15, 29  
365 G → A  2  29  
 ΔA  1  15  
423 C → G  2  15, 27  
 ΔC  1  29 
437  G → T* 2  Present study, 15  
 G → A 2  15, 26  
520  ΔT  4  Present study 
748  ΔT  2  15, 28  
 +T  15, 28  
 T → G  1  27 
Position Mutation Number of Reported MutationsReference
84  G → A  2  15, 26  
 G → C 1  26  
 G → T  1  27  
122  G → C  29  
 G → A* 3  26, 27  
123  C → T  Present study, 15, 26  
 C → G  2  15, 26  
186 T → C  3  Present study, 26  
190  T → C  Present study  
 T → A  2  15, 29  
365 G → A  2  29  
 ΔA  1  15  
423 C → G  2  15, 27  
 ΔC  1  29 
437  G → T* 2  Present study, 15  
 G → A 2  15, 26  
520  ΔT  4  Present study 
748  ΔT  2  15, 28  
 +T  15, 28  
 T → G  1  27 

Only nucleotide positions affected by mutations 3 or more times are included in the table.

*

Denotes mutations that were also reported in normal germinal center lymphocytes (14).

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