Table 1. Clinical features of the... | American Society of Hematology

Table 1.

Clinical features of the patients

Family No.	Relation	Age	WBC Count (×103/uL)	Rai Stage	Duration of Disease (y)^*	Mutations of VH Genes^†
1a	Mother	75	41.6	0	1	−
1b	Son	56	34.3	0	1	−
2a	Sister	73	30.7	II	20	+
2b	Brother	59	33.6	IV	10	+
3a	Sister	62	21.9	I	<1	+
3b	Sister	61	22.1	I	4	+
4a	Sister	74	16.5	I	4	+
4b	Sister	75	77.4	I	18	+
4c	Brother	72	16.1	IV	2	+
5a	Brother	54	6.1	I	5	−
5b	Sister	51	124.0	0	4	−
6a	Brother	56	27.7	I	1	−
6b	Brother	53	42.5	I	3	−
7a	Brother	75	8.0	0	9	+
7b	Brother	72	13.3	I	<1	+
8a	Brother	50	27.9	0	3	+
8b	Brother	64	70.9	II	2	−
9a	Sister	40	95.8	I	3	−
9b	Brother	43	58.0	I	1	−
10a	Sister	57	148.8	I	8	−
10b	Brother	45	97.1	I	1	−
11a	Brother	65	15.9	I	<1	−
11b	Sister	62	8.8	0	<1	+

Family No.	Relation	Age	WBC Count (×103/uL)	Rai Stage	Duration of Disease (y)^*	Mutations of VH Genes^†
1a	Mother	75	41.6	0	1	−
1b	Son	56	34.3	0	1	−
2a	Sister	73	30.7	II	20	+
2b	Brother	59	33.6	IV	10	+
3a	Sister	62	21.9	I	<1	+
3b	Sister	61	22.1	I	4	+
4a	Sister	74	16.5	I	4	+
4b	Sister	75	77.4	I	18	+
4c	Brother	72	16.1	IV	2	+
5a	Brother	54	6.1	I	5	−
5b	Sister	51	124.0	0	4	−
6a	Brother	56	27.7	I	1	−
6b	Brother	53	42.5	I	3	−
7a	Brother	75	8.0	0	9	+
7b	Brother	72	13.3	I	<1	+
8a	Brother	50	27.9	0	3	+
8b	Brother	64	70.9	II	2	−
9a	Sister	40	95.8	I	3	−
9b	Brother	43	58.0	I	1	−
10a	Sister	57	148.8	I	8	−
10b	Brother	45	97.1	I	1	−
11a	Brother	65	15.9	I	<1	−
11b	Sister	62	8.8	0	<1	+

Expressed in years from time of diagnosis.

Mutations of immunoglobin heavy-chain variable region (VH): +, presence of somatic mutations; −, absence of somatic mutations.