Effects of ATIII treatment on physiological responses in baboons after infusion of lethal E coli
| Time (h) . | 0 . | 1 . | 2 . | 4 . | 6 . | 8 . | 10 . |
|---|---|---|---|---|---|---|---|
| MSAP | |||||||
| Control | 119.4 ± 6.7 | 109 ± 2.9 | 74.4 ± 7.4 | 61.6 ± 7.8 | 72.2 ± 4.4 | 72.6 ± 10.6 | 68.6 ± 1.09 |
| ATIII | 126.6 ± 4.6 | 108.4 ± 7.4 | 74.6 ± 10 | 80 ± 11.2 | 83.4 ± 7.3 | 81 ± 6.2 | 79.4 ± 7.2 |
| HR | |||||||
| Control | 136 ± 11.2 | 156 ± 12.9 | 176 ± 9.3 | 193 ± 8.8 | 190 ± 10 | 192 ± 9.7 | 195 ± 8.7 |
| ATIII | 144 ± 9.3 | 178 ± 16.2 | 207 ± 14.3 | 204 ± 12.1 | 205 ± 12 | 207 ± 8.3 | 207 ± 8.6 |
| TEMP | |||||||
| Control | 36.4 ± 0.5 | 35.9 ± 0.3 | 36.4 ± 0.4 | 37.1 ± 0.4 | 37.1 ± 0.4 | 37.3 ± 0.6 | 36.9 ± 0.4 |
| ATIII | 37.1 ± 0.1 | 37.3 ± 0.2 | 38.3 ± 0.3 | 38.4 ± 0.2 | 38.3 ± 0.3 | 38.2 ± 0.3 | 38.3 ± 0.2 |
| WBC | |||||||
| Control | 5.8 ± 1.7 | 2.3 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.2 | 1.6 ± 0.2 | ND | 2.7 ± 0.3 |
| ATIII | 13.2 ± 3 | 3.2 ± 1 | 1.3 ± 0.2 | 1.8 ± 0.3 | 2.2 ± 0.3 | ND | 3.1 ± 0.6 |
| PLT | |||||||
| Control | 323 ± 26 | 255 ± 18 | 215 ± 17 | 175 ± 16 | 150 ± 14 | ND | 124 ± 25 |
| ATIII | 307 ± 46 | 220 ± 28 | 207 ± 29 | 177 ± 30 | 159 ± 28 | ND | 85 ± 16 |
| HCT | |||||||
| Control | 37.2 ± 1.1 | 39.8 ± 1.3 | 37.4 ± 1.3 | 37.8 ± 1.8 | 40.2 ± 1.6 | ND | 41.6 ± 1.0 |
| ATIII | 41.4 ± 1.1 | 41 ± 1 | 38.6 ± 1.2 | 41 ± 1.8 | 40.8 ± 1.2 | ND | 40.2 ± 2.1 |
| Time (h) . | 0 . | 1 . | 2 . | 4 . | 6 . | 8 . | 10 . |
|---|---|---|---|---|---|---|---|
| MSAP | |||||||
| Control | 119.4 ± 6.7 | 109 ± 2.9 | 74.4 ± 7.4 | 61.6 ± 7.8 | 72.2 ± 4.4 | 72.6 ± 10.6 | 68.6 ± 1.09 |
| ATIII | 126.6 ± 4.6 | 108.4 ± 7.4 | 74.6 ± 10 | 80 ± 11.2 | 83.4 ± 7.3 | 81 ± 6.2 | 79.4 ± 7.2 |
| HR | |||||||
| Control | 136 ± 11.2 | 156 ± 12.9 | 176 ± 9.3 | 193 ± 8.8 | 190 ± 10 | 192 ± 9.7 | 195 ± 8.7 |
| ATIII | 144 ± 9.3 | 178 ± 16.2 | 207 ± 14.3 | 204 ± 12.1 | 205 ± 12 | 207 ± 8.3 | 207 ± 8.6 |
| TEMP | |||||||
| Control | 36.4 ± 0.5 | 35.9 ± 0.3 | 36.4 ± 0.4 | 37.1 ± 0.4 | 37.1 ± 0.4 | 37.3 ± 0.6 | 36.9 ± 0.4 |
| ATIII | 37.1 ± 0.1 | 37.3 ± 0.2 | 38.3 ± 0.3 | 38.4 ± 0.2 | 38.3 ± 0.3 | 38.2 ± 0.3 | 38.3 ± 0.2 |
| WBC | |||||||
| Control | 5.8 ± 1.7 | 2.3 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.2 | 1.6 ± 0.2 | ND | 2.7 ± 0.3 |
| ATIII | 13.2 ± 3 | 3.2 ± 1 | 1.3 ± 0.2 | 1.8 ± 0.3 | 2.2 ± 0.3 | ND | 3.1 ± 0.6 |
| PLT | |||||||
| Control | 323 ± 26 | 255 ± 18 | 215 ± 17 | 175 ± 16 | 150 ± 14 | ND | 124 ± 25 |
| ATIII | 307 ± 46 | 220 ± 28 | 207 ± 29 | 177 ± 30 | 159 ± 28 | ND | 85 ± 16 |
| HCT | |||||||
| Control | 37.2 ± 1.1 | 39.8 ± 1.3 | 37.4 ± 1.3 | 37.8 ± 1.8 | 40.2 ± 1.6 | ND | 41.6 ± 1.0 |
| ATIII | 41.4 ± 1.1 | 41 ± 1 | 38.6 ± 1.2 | 41 ± 1.8 | 40.8 ± 1.2 | ND | 40.2 ± 2.1 |
Values represent mean ± SEM of mean arterial pressure (MSAP, mm Hg), heart rate (HR, beats/min), temperature (temp, °C), white blood cell counts (WBC, 103/mm3), platelets (PLT, 103/mm3), and hematocrit (HCT, %). The course of the parameters was different between groups for WBC at t = 0 and for temperature (P < .05). ND indicates not determined.