The Val34Leu polymorphism in the A-subunit of the factor XIII gene in cases with brain infarction and controls
| N (%) . | Val/Val . | Val/Leu . | Leu/Leu . | P . | Leu% . | OR (95% CI) . | OR (95% CI)† . | Cases and matched controls free of cardio- and cerebrovascular history . | |
|---|---|---|---|---|---|---|---|---|---|
| N . | OR (95% CI)‡ . | . | |||||||
| All strokes | |||||||||
| Controls2-153 | 227 (49.8) | 195 (42.8) | 34 (7.4) | <10−3 | 28.8 | 0.58 (0.44-0.75) | 0.53 (0.40-0.70) | 262 | 0.51 (0.36-0.73) |
| Cases | 288 (63.2) | 141 (30.9) | 27 (5.9) | 21.4 | |||||
| Atherothrombotic strokes | |||||||||
| Controls | 54 (51.4) | 44 (41.9) | 7 (6.7) | .12 | 27.6 | 0.63 (0.37-1.10) | 0.57 (0.32-1.03) | 56 | 0.52 (0.25-1.11) |
| Cases | 66 (62.9) | 29 (27.6) | 10 (9.5) | 23.3 | |||||
| Lacunar strokes | |||||||||
| Controls | 37 (39.4) | 49 (52.1) | 8 (8.5) | .004 | 34.6 | 0.32 (0.16-0.65) | 0.29 (0.14-0.63) | 59 | 0.24 (0.09-0.65) |
| Cases | 58 (61.7) | 29 (30.8) | 7 (7.5) | 22.9 | |||||
| Cardioembolic strokes | |||||||||
| Controls | 36 (49.3) | 31 (42.5) | 6 (8.2) | .06 | 29.5 | 0.47 (0.23-0.94) | 0.38 (0.18-0.82) | 41 | 0.35 (0.12-1.05) |
| Cases | 49 (67.1) | 22 (30.1) | 2 (2.7) | 17.8 | |||||
| Strokes of unknown cause | |||||||||
| Controls | 58 (54.7) | 43 (40.6) | 5 (4.7) | .68 | 25.0 | 0.85 (0.49-1.46) | 0.77 (0.44-1.35) | 65 | 0.87 (0.43-1.76) |
| Cases | 63 (59.4) | 37 (34.9) | 6 (5.7) | 23.1 | |||||
| N (%) . | Val/Val . | Val/Leu . | Leu/Leu . | P . | Leu% . | OR (95% CI) . | OR (95% CI)† . | Cases and matched controls free of cardio- and cerebrovascular history . | |
|---|---|---|---|---|---|---|---|---|---|
| N . | OR (95% CI)‡ . | . | |||||||
| All strokes | |||||||||
| Controls2-153 | 227 (49.8) | 195 (42.8) | 34 (7.4) | <10−3 | 28.8 | 0.58 (0.44-0.75) | 0.53 (0.40-0.70) | 262 | 0.51 (0.36-0.73) |
| Cases | 288 (63.2) | 141 (30.9) | 27 (5.9) | 21.4 | |||||
| Atherothrombotic strokes | |||||||||
| Controls | 54 (51.4) | 44 (41.9) | 7 (6.7) | .12 | 27.6 | 0.63 (0.37-1.10) | 0.57 (0.32-1.03) | 56 | 0.52 (0.25-1.11) |
| Cases | 66 (62.9) | 29 (27.6) | 10 (9.5) | 23.3 | |||||
| Lacunar strokes | |||||||||
| Controls | 37 (39.4) | 49 (52.1) | 8 (8.5) | .004 | 34.6 | 0.32 (0.16-0.65) | 0.29 (0.14-0.63) | 59 | 0.24 (0.09-0.65) |
| Cases | 58 (61.7) | 29 (30.8) | 7 (7.5) | 22.9 | |||||
| Cardioembolic strokes | |||||||||
| Controls | 36 (49.3) | 31 (42.5) | 6 (8.2) | .06 | 29.5 | 0.47 (0.23-0.94) | 0.38 (0.18-0.82) | 41 | 0.35 (0.12-1.05) |
| Cases | 49 (67.1) | 22 (30.1) | 2 (2.7) | 17.8 | |||||
| Strokes of unknown cause | |||||||||
| Controls | 58 (54.7) | 43 (40.6) | 5 (4.7) | .68 | 25.0 | 0.85 (0.49-1.46) | 0.77 (0.44-1.35) | 65 | 0.87 (0.43-1.76) |
| Cases | 63 (59.4) | 37 (34.9) | 6 (5.7) | 23.1 | |||||
Using conditional logistic regression for matched sets. ORs are computed by comparing the frequency of carriers of the Leu allele (Val/Leu + Leu/Leu genotypes) with the frequency of Val/Val homozygotes in cases and controls.
Using conditional logistic regression for matched sets, after adjustment for cardiovascular history.
Using conditional logistic regression for matched sets, after restricting the analysis to cases and matched controls free of cardiovascular and cerebrovascular history (N is the number of matched pairs).
Test for Hardy-Weinberg equilibrium: P = .42.