Hemopoietic progenitor cells in double mutant mice
| Colony Number . | Genotype . | |||||
|---|---|---|---|---|---|---|
| Wild Type . | LIF−/− . | IL-6−/− . | mpl−/− . | mpl−/−LIF−/− . | mpl−/−IL-6−/− . | |
| Bone marrow (per 25 000 cells) | ||||||
| Blast | 15 ± 3 | 14 ± 1 | 9 ± 0 | 2 ± 1 | 2 ± 2 | 2 ± 2 |
| Granulocyte | 36 ± 7 | 20 ± 43-150 | 31 ± 17 | 13 ± 8 | 20 ± 13 | 20 ± 1 |
| Mixed granulocyte/macrophage | 41 ± 15 | 22 ± 10 | 21 ± 5 | 8 ± 5 | 18 ± 6 | 13 ± 7 |
| Macrophage | 27 ± 6 | 20 ± 10 | 32 ± 22 | 13 ± 8 | 24 ± 12 | 28 ± 53-150 |
| Eosinophil | 5 ± 1 | 2 ± 13-150 | 3 ± 1 | 0.5 ± 0.6 | 1 ± 2 | 2 ± 2 |
| Spleen (per 100 000) cells | ||||||
| Blast | 3 ± 3 | 1 ± 1 | 3 ± 4 | 0.3 ± 0.5 | 1 ± 2 | 0 |
| Granulocyte | 3 ± 2 | 0.5 ± 0.7 | 2 ± 0 | 2 ± 1 | 0.3 ± 0.6 | 1 ± 1 |
| Mixed granulocyte/macrophage | 1 ± 1 | 0 | 0.5 ± 0.7 | 0 | 0.3 ± 0.6 | 0.3 ± 0.6 |
| Macrophage | 2 ± 2 | 0 | 2 ± 0 | 0.3 ± 0.5 | 0.3 ± 0.6 | 0.3 ± 0.6 |
| Eosinophil | 0.3 ± 0.5 | 0 | 0 | 0 | 0 | 0 |
| Colony Number . | Genotype . | |||||
|---|---|---|---|---|---|---|
| Wild Type . | LIF−/− . | IL-6−/− . | mpl−/− . | mpl−/−LIF−/− . | mpl−/−IL-6−/− . | |
| Bone marrow (per 25 000 cells) | ||||||
| Blast | 15 ± 3 | 14 ± 1 | 9 ± 0 | 2 ± 1 | 2 ± 2 | 2 ± 2 |
| Granulocyte | 36 ± 7 | 20 ± 43-150 | 31 ± 17 | 13 ± 8 | 20 ± 13 | 20 ± 1 |
| Mixed granulocyte/macrophage | 41 ± 15 | 22 ± 10 | 21 ± 5 | 8 ± 5 | 18 ± 6 | 13 ± 7 |
| Macrophage | 27 ± 6 | 20 ± 10 | 32 ± 22 | 13 ± 8 | 24 ± 12 | 28 ± 53-150 |
| Eosinophil | 5 ± 1 | 2 ± 13-150 | 3 ± 1 | 0.5 ± 0.6 | 1 ± 2 | 2 ± 2 |
| Spleen (per 100 000) cells | ||||||
| Blast | 3 ± 3 | 1 ± 1 | 3 ± 4 | 0.3 ± 0.5 | 1 ± 2 | 0 |
| Granulocyte | 3 ± 2 | 0.5 ± 0.7 | 2 ± 0 | 2 ± 1 | 0.3 ± 0.6 | 1 ± 1 |
| Mixed granulocyte/macrophage | 1 ± 1 | 0 | 0.5 ± 0.7 | 0 | 0.3 ± 0.6 | 0.3 ± 0.6 |
| Macrophage | 2 ± 2 | 0 | 2 ± 0 | 0.3 ± 0.5 | 0.3 ± 0.6 | 0.3 ± 0.6 |
| Eosinophil | 0.3 ± 0.5 | 0 | 0 | 0 | 0 | 0 |
Mean ± SD, n = 2 to 4 mice of each genotype.
P < .05 for comparison of data from LIF−/−, IL-6−/−, or IL-11R−/− mice with wild-type controls or of LIF−/− mpl−/−, IL-6−/− mpl−/−, or IL-11Rα−/− mpl−/− mice with mpl−/− data. No other statistically significant differences were observed.