Table 4.

Clinical Characteristics, Karyotypes, and Outcome for Patients With Less Than 45 Chromosomes

Patient No. Modal Chromosome Number RaceNCI Risk Group Karyotype Outcome
1  24  White Standard  24,X,+21/48,idem,x2/46,XX  Alive postrelapse 
2  25  White  Standard  25,X,−Y,+14,+21/46,XY Died postrelapse  
3  26  White  Poor 26,X,+Y,+14,+21/46,XY  Died in first remission  
4 26  White  Poor  26,XY,+del(5)(q13q33),+21/52,idem,x2 Died after a postrelapse BMT  
5  27  White Standard  27,X,+X,+18,+21,+mar/46,XX  Alive, event-free 
6  27  Black  Poor 27,X,+Y,+del(13)(q1?4q2?2),+18,+21/27,idem,−del(13)(q1?4q2?2), +dup(13)(q1?3q1?4)/46,XY  Alive, event-free after a BMT in first remission  
7  27  Other4-150 Poor 27,X,+8,+10,+18,+21/46,XX  Alive postrelapse  
8  28 White  Standard  28,X,+8,+9,+10,+18,+21/46,XX  Died postrelapse  
9  33  White  Poor 33〈1n〉,X,+1,+2,+3,+6,+7,+8,+10,+11,+12,+15, +16,−22/46,XY  Alive, event-free  
10  34  Hispanic  Poor 34〈1n〉,X,+Y,+1,+5,+6,+8,+10,+11,+18,+19,+21, +22/46,XY Died postrelapse  
11  34  White  Poor 34〈1n〉,X,+1,+5,+6,inv(7)(p1?5q11.2),+8,+10,+11, +13,+14,+19,+21,+22/69〈3n〉,XX,−X,+1,−2, −3,−4,+5,+6, inv(7)(p1?5q11.2),−9,+11,−12, +13,+14,−15, −16,−17,−18,+19,+20,+21, +22/46, XX  Died after a postrelapse BMT  
12  36  White  Poor 36,XX,−3,−4,−5,−7,−9,−13,−15,−16,−17,−17, −20,+mar/72,idemx2/46, XX  Alive, event-free  
134-151 40  White  Poor 40,X,−Y,−3,der(4)t(3;4)(p21;p16),−7,−9,−15,−16, −17,−18,+2mar/46, XY  Alive, event-free  
14‡ 42  White  Standard 42,XY,−3,−5,der(6)t(6;7)(p25;q11.2),−7,add(8)(p21),der(9)t(9;12) (p22;p13) t(9;22)(q34;q11),der(12)t(9;12)(p22;p13),−13, der(15;17) (q10;q10),add(22)(p11),+mar/46,XY  Died post-2nd relapse, after a first remission BMT  
15  43  White  Poor 43,X,−X,add(1)(p3?4),t(2;12)(p21;p13),−7,t(7;9)(p13;p22),add(12)(p11), −15/46,XX  Died, postrelapse  
16  44  White Standard 44,XX,der(2)t(2;7)(q31;p15),−7,psudic(9;16)(p2?2;p1?1.2),der(12)t(7;12)(q1?1.2;p11.2)/45, idem,+mar/46,XX  Alive, postrelapse  
17  44  White Standard  44,X,−Y,add(12)(p11),−13/46,XY  Alive, event-free  
18  44  White  Poor 44,X,−X,−6,der(9)t(6;9)(p11.1;p13)/46,XX  Alive, event-free  
19  44  Hispanic  Standard 44,XY,add(1)(q4?),del(2)(p1?),add(6)(p21),add(11) (p11.1),?i(12)(p10)x2, −14,−20,−21,+mar/46,XY  Alive, event-free  
20  44 White  Poor 44,X,−Y,der(6)del(6)(p22)del(6)(q12),i(9)(q10), der(12)t(12;14)(p1?3;q11.2 ),−14,add(14)(q32), add(16)(p13)/46,XY  Died in first remission  
21  44  White  Poor 44,XX,der(4)t(4;18)(p1?5;q11∼21),add(9)(p13),−18,−20/46,XX Died postrelapse  
22  44  Black  Standard 44,X,−Y,add(9)(p22),del(11)(q2?1q2?3),−13,add(17) (p1?3),der(19)t(1;19) (q23;p13)/46,XY  Died postrelapse  
23  44  White Standard  44,XY,dic(9;12)(p11;p12),−15  Died postrelapse 
Patient No. Modal Chromosome Number RaceNCI Risk Group Karyotype Outcome
1  24  White Standard  24,X,+21/48,idem,x2/46,XX  Alive postrelapse 
2  25  White  Standard  25,X,−Y,+14,+21/46,XY Died postrelapse  
3  26  White  Poor 26,X,+Y,+14,+21/46,XY  Died in first remission  
4 26  White  Poor  26,XY,+del(5)(q13q33),+21/52,idem,x2 Died after a postrelapse BMT  
5  27  White Standard  27,X,+X,+18,+21,+mar/46,XX  Alive, event-free 
6  27  Black  Poor 27,X,+Y,+del(13)(q1?4q2?2),+18,+21/27,idem,−del(13)(q1?4q2?2), +dup(13)(q1?3q1?4)/46,XY  Alive, event-free after a BMT in first remission  
7  27  Other4-150 Poor 27,X,+8,+10,+18,+21/46,XX  Alive postrelapse  
8  28 White  Standard  28,X,+8,+9,+10,+18,+21/46,XX  Died postrelapse  
9  33  White  Poor 33〈1n〉,X,+1,+2,+3,+6,+7,+8,+10,+11,+12,+15, +16,−22/46,XY  Alive, event-free  
10  34  Hispanic  Poor 34〈1n〉,X,+Y,+1,+5,+6,+8,+10,+11,+18,+19,+21, +22/46,XY Died postrelapse  
11  34  White  Poor 34〈1n〉,X,+1,+5,+6,inv(7)(p1?5q11.2),+8,+10,+11, +13,+14,+19,+21,+22/69〈3n〉,XX,−X,+1,−2, −3,−4,+5,+6, inv(7)(p1?5q11.2),−9,+11,−12, +13,+14,−15, −16,−17,−18,+19,+20,+21, +22/46, XX  Died after a postrelapse BMT  
12  36  White  Poor 36,XX,−3,−4,−5,−7,−9,−13,−15,−16,−17,−17, −20,+mar/72,idemx2/46, XX  Alive, event-free  
134-151 40  White  Poor 40,X,−Y,−3,der(4)t(3;4)(p21;p16),−7,−9,−15,−16, −17,−18,+2mar/46, XY  Alive, event-free  
14‡ 42  White  Standard 42,XY,−3,−5,der(6)t(6;7)(p25;q11.2),−7,add(8)(p21),der(9)t(9;12) (p22;p13) t(9;22)(q34;q11),der(12)t(9;12)(p22;p13),−13, der(15;17) (q10;q10),add(22)(p11),+mar/46,XY  Died post-2nd relapse, after a first remission BMT  
15  43  White  Poor 43,X,−X,add(1)(p3?4),t(2;12)(p21;p13),−7,t(7;9)(p13;p22),add(12)(p11), −15/46,XX  Died, postrelapse  
16  44  White Standard 44,XX,der(2)t(2;7)(q31;p15),−7,psudic(9;16)(p2?2;p1?1.2),der(12)t(7;12)(q1?1.2;p11.2)/45, idem,+mar/46,XX  Alive, postrelapse  
17  44  White Standard  44,X,−Y,add(12)(p11),−13/46,XY  Alive, event-free  
18  44  White  Poor 44,X,−X,−6,der(9)t(6;9)(p11.1;p13)/46,XX  Alive, event-free  
19  44  Hispanic  Standard 44,XY,add(1)(q4?),del(2)(p1?),add(6)(p21),add(11) (p11.1),?i(12)(p10)x2, −14,−20,−21,+mar/46,XY  Alive, event-free  
20  44 White  Poor 44,X,−Y,der(6)del(6)(p22)del(6)(q12),i(9)(q10), der(12)t(12;14)(p1?3;q11.2 ),−14,add(14)(q32), add(16)(p13)/46,XY  Died in first remission  
21  44  White  Poor 44,XX,der(4)t(4;18)(p1?5;q11∼21),add(9)(p13),−18,−20/46,XX Died postrelapse  
22  44  Black  Standard 44,X,−Y,add(9)(p22),del(11)(q2?1q2?3),−13,add(17) (p1?3),der(19)t(1;19) (q23;p13)/46,XY  Died postrelapse  
23  44  White Standard  44,XY,dic(9;12)(p11;p12),−15  Died postrelapse 
F4-150

Race other than white, black, or hispanic.

F4-151

Bone marrow transplant in remission.

‡

Ph+ patient.

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