Table 8.

Published Studies Exploring the Association Between Low-Affinity FcγR Genotypes and Phenotype Within a Single Disease Population

FcγRIIa
Primary Disease Endpoint Association by Locus Overall (3 × 2 table; P value)Association by Genotype (2 × 2 table; HHv HR + RR, RR v HR + HH, P value)Genotype: Patients Without EndpointGenotype: Patients With EndpointCountry/ Ethnic Group Reference
HH HRRR HH HR RR
SLE  Nephritis  .94  .036 .20  25  49  37  12  48  43  USA/AA Salmon58 
SLE  Nephritis  .20  .077 .28  27  19  15  13  18  16  Germany/CA Manger40 
SLE  Nephritis  .29  .28f .76f  7  39  12  5  10  5  UK/CA Smyth50 
SLE  Nephritis  .51  .38 .77  9  7  7  5  9  5  Greece/CA Smyth50 
SLE  Nephritis  .074  .19 .029  11  26  8  7  24  19  Netherlands/CA Duits49 
SLE  Nephritis  .68  .38 .77  57  120  82  9  13  9  UK/CA Botto38 
SLE  Nephritis  .63 .39 1.00f  17  35  25  2  9  5  Caribbean/AA Botto38 
Subtotal:  Nephritis  .55 .69  111  211  124  39  74  54  CA 
SLE    .27  
  .57  .019  42  84 62  14  57  48  AA  
   .19  
  .07  .059  153  295  186  53  131  102 Total  
   .055         
SLE  Proteinuria  .077 .024 .21  31  21  17  9  16  14  Germany/CA Manger40 
SLE  Hemolytic anemia  .0173 .0034f .084  40  31  25  0  6  6  Germany/CA Manger40 
Wegener's granulomatosis  Renal dysfunction  .68  .38 .72  20  25  10  27  46  19  USA/CA Edberg41 
N meningitides Infection Severe disease  .020  .011 .034  18  19  10  8  22  21  Russia/CA Platonov64 
Complement deficiency  N meningitides >10 yr  .057  .046f 1.00f  8  4  2  2  9  3  Russia/CA Platonov43 
Late complement deficiency Severe N meningitides ND  .0039f ND  17  17RR+HR 14RR+HR Russia/CA Platonov43 
HIV (Children)  S pneumoniae infection  .9377  1.00f 1.00f  7* 23* 10* 1  5  USA/HI  Abadi52 
HIV  S pneumoniae infection  .78  .66f .68f  7* 23* 10* 2  4  USA/HI  Abadi52 
Myasthenia gravis Thymoma  .048  .026f 1.00f  5  12  6  5  1  1  Norway/CA Raknes32 
Periodontitis  Disease recurrence .57  .74 .59f  9  6  0  47  32  6  Japan/PR Kobayashi31 
CGD  Granuloma  .14 .049 .59  13  40  19  18  24  12  USA/ED Foster33 
CGD  Autoimmune  .029 .69f .039f  28  63  26  3  1  5  USA/ED Foster33 
HIT  Thrombosis  .036  .12 .014  13  30  25  17  28  9  Germany/ED Carlsson66 
HIT  Thrombosis .69  .68f 1.00f  2  8  3  6  11  6  USA/ED Arepally44 
FcγRIIIb
 
Primary Disease  Endpoint  Association by Locus Overall (3 × 2 table; P value) Association by Genotype (2 × 2 table; 1/1v 1/2 + 2/2, 2/2 v 1/1 + 1/2, Pvalue)  Genotype: Patients Without Endpoint  Genotype: Patients With Endpoint Country/ Ethnic Group  Reference  
1/1  1/2  2/2  1/1 1/2  2/2  
Periodontitis  Disease recurrence  .032 .0098 .29f  10  4  1  27  39  19  Japan/PR Kobayashi31 
CGD  Granuloma  .022 .0066f .65  12  30  31  1  29  26  USA/ED Foster33 
FcγRIIa
Primary Disease Endpoint Association by Locus Overall (3 × 2 table; P value)Association by Genotype (2 × 2 table; HHv HR + RR, RR v HR + HH, P value)Genotype: Patients Without EndpointGenotype: Patients With EndpointCountry/ Ethnic Group Reference
HH HRRR HH HR RR
SLE  Nephritis  .94  .036 .20  25  49  37  12  48  43  USA/AA Salmon58 
SLE  Nephritis  .20  .077 .28  27  19  15  13  18  16  Germany/CA Manger40 
SLE  Nephritis  .29  .28f .76f  7  39  12  5  10  5  UK/CA Smyth50 
SLE  Nephritis  .51  .38 .77  9  7  7  5  9  5  Greece/CA Smyth50 
SLE  Nephritis  .074  .19 .029  11  26  8  7  24  19  Netherlands/CA Duits49 
SLE  Nephritis  .68  .38 .77  57  120  82  9  13  9  UK/CA Botto38 
SLE  Nephritis  .63 .39 1.00f  17  35  25  2  9  5  Caribbean/AA Botto38 
Subtotal:  Nephritis  .55 .69  111  211  124  39  74  54  CA 
SLE    .27  
  .57  .019  42  84 62  14  57  48  AA  
   .19  
  .07  .059  153  295  186  53  131  102 Total  
   .055         
SLE  Proteinuria  .077 .024 .21  31  21  17  9  16  14  Germany/CA Manger40 
SLE  Hemolytic anemia  .0173 .0034f .084  40  31  25  0  6  6  Germany/CA Manger40 
Wegener's granulomatosis  Renal dysfunction  .68  .38 .72  20  25  10  27  46  19  USA/CA Edberg41 
N meningitides Infection Severe disease  .020  .011 .034  18  19  10  8  22  21  Russia/CA Platonov64 
Complement deficiency  N meningitides >10 yr  .057  .046f 1.00f  8  4  2  2  9  3  Russia/CA Platonov43 
Late complement deficiency Severe N meningitides ND  .0039f ND  17  17RR+HR 14RR+HR Russia/CA Platonov43 
HIV (Children)  S pneumoniae infection  .9377  1.00f 1.00f  7* 23* 10* 1  5  USA/HI  Abadi52 
HIV  S pneumoniae infection  .78  .66f .68f  7* 23* 10* 2  4  USA/HI  Abadi52 
Myasthenia gravis Thymoma  .048  .026f 1.00f  5  12  6  5  1  1  Norway/CA Raknes32 
Periodontitis  Disease recurrence .57  .74 .59f  9  6  0  47  32  6  Japan/PR Kobayashi31 
CGD  Granuloma  .14 .049 .59  13  40  19  18  24  12  USA/ED Foster33 
CGD  Autoimmune  .029 .69f .039f  28  63  26  3  1  5  USA/ED Foster33 
HIT  Thrombosis  .036  .12 .014  13  30  25  17  28  9  Germany/ED Carlsson66 
HIT  Thrombosis .69  .68f 1.00f  2  8  3  6  11  6  USA/ED Arepally44 
FcγRIIIb
 
Primary Disease  Endpoint  Association by Locus Overall (3 × 2 table; P value) Association by Genotype (2 × 2 table; 1/1v 1/2 + 2/2, 2/2 v 1/1 + 1/2, Pvalue)  Genotype: Patients Without Endpoint  Genotype: Patients With Endpoint Country/ Ethnic Group  Reference  
1/1  1/2  2/2  1/1 1/2  2/2  
Periodontitis  Disease recurrence  .032 .0098 .29f  10  4  1  27  39  19  Japan/PR Kobayashi31 
CGD  Granuloma  .022 .0066f .65  12  30  31  1  29  26  USA/ED Foster33 

Table 8 includes published studies in which the raw numbers were available for recalculation. Studies listed more than once and report distinct populations in the paper are treated as separate populations for the purpose of the analysis. Analysis of individual studies and subtotals of comparable studies were analyzed by χ2 3 × 2 test (with 2 degrees of freedom) for overall significance and also by χ2 2 × 2 test (with 1 degree of freedom) for each genotype, when relevant. Raw values are presented and not corrected in the table. Thus, values may differ from the published data because of correction factors determined by the investigators. In selected studies in which there were too few measurements in a cell, the Fischer exact test was performed and is indicated by an f. The following symbols indicate ethnic background: CA, Caucasians (European/North American background); AA, African Americans; PR, Pacific Rim; HI, Hispanic; ED, ethnically diverse.

Abbreviations: SLE, systemic lupus erythematosus; HIT, heparin induced thrombocytopenia; ITP, idiopathic thrombocytopenia purpura; HIV, human immunodeficiency virus infection; CGD, chronic granulomatous disease.

*Indicates a control population used for multiple comparisons; however, the numbers were included only once in the sum for the meta-analysis.

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