Leukocyte Chimerism in 22 Patients With B+SCID After BMT
. | UPN . | Molecular Deficiency . | Age at BMT (mos) . | Follow-Up (yrs) . | CR . | Chimerism . | |||
---|---|---|---|---|---|---|---|---|---|
T Cells . | B Cells . | Monocytes . | NK Cells . | ||||||
HLA-identical BMT | 17 | γc | 1 | 23 | No | D | H | H | (−) |
116* | γc | 1 | 13 | No | D | H | H | D | |
261 | γc | 6.5 | 5.5 | No | D | H | H | ND | |
50 | Unknown | 4.5 | 13.5 | No | D | D/H | H | D | |
299 | Unknown | 10 | 4.5 | No | D | H | H | H | |
HLA-nonidentical BMT | 51* | γc | 2.5 | 13 | No | D | H | H | ND |
122 | γc | 6.5 | 10 | No | D | D | D | ND | |
307 | γc | 93 | 3.5 | No | D | H | H | (−) | |
325 | γc | 14 | 3 | No | D | H | H | D | |
277 | γc | 8 | 4.5 | No | D | H | H | ND | |
57 | JAK3 | 9 | 13 | No | D | H | H | (−) | |
223 | JAK3 | 11 | 6.5 | No | D | D | D | ND | |
365 | JAK3 | 5 | 2 | No | D | H | H | D | |
168 | γc | 2 | 8.5 | Yes | D | H | H | ND | |
272b | γc | 29 | 3 | Yes | D | H | H | D | |
303 | γc | 1 | 4 | Yes | D | H | H | D | |
308 | γc | 8.5 | 3.5 | Yes | D | H | H | ND | |
318 | γc | 5.5 | 3 | Yes | D | H | H | ND | |
348 | γc | 1 | 2 | Yes | D | H | H | D | |
158 | Unknown | 4 | 9 | Yes | D | H | H | D | |
360 | Unknown | 10 | 2 | Yes | D | H | H | D | |
221 | JAK3 | 11 | 6.5 | Yes | D | D | D | D |
. | UPN . | Molecular Deficiency . | Age at BMT (mos) . | Follow-Up (yrs) . | CR . | Chimerism . | |||
---|---|---|---|---|---|---|---|---|---|
T Cells . | B Cells . | Monocytes . | NK Cells . | ||||||
HLA-identical BMT | 17 | γc | 1 | 23 | No | D | H | H | (−) |
116* | γc | 1 | 13 | No | D | H | H | D | |
261 | γc | 6.5 | 5.5 | No | D | H | H | ND | |
50 | Unknown | 4.5 | 13.5 | No | D | D/H | H | D | |
299 | Unknown | 10 | 4.5 | No | D | H | H | H | |
HLA-nonidentical BMT | 51* | γc | 2.5 | 13 | No | D | H | H | ND |
122 | γc | 6.5 | 10 | No | D | D | D | ND | |
307 | γc | 93 | 3.5 | No | D | H | H | (−) | |
325 | γc | 14 | 3 | No | D | H | H | D | |
277 | γc | 8 | 4.5 | No | D | H | H | ND | |
57 | JAK3 | 9 | 13 | No | D | H | H | (−) | |
223 | JAK3 | 11 | 6.5 | No | D | D | D | ND | |
365 | JAK3 | 5 | 2 | No | D | H | H | D | |
168 | γc | 2 | 8.5 | Yes | D | H | H | ND | |
272b | γc | 29 | 3 | Yes | D | H | H | D | |
303 | γc | 1 | 4 | Yes | D | H | H | D | |
308 | γc | 8.5 | 3.5 | Yes | D | H | H | ND | |
318 | γc | 5.5 | 3 | Yes | D | H | H | ND | |
348 | γc | 1 | 2 | Yes | D | H | H | D | |
158 | Unknown | 4 | 9 | Yes | D | H | H | D | |
360 | Unknown | 10 | 2 | Yes | D | H | H | D | |
221 | JAK3 | 11 | 6.5 | Yes | D | D | D | D |
Abbreviations: H, cells of host origin; D, cells of donor origin; ND, not done; (−), cells not found.
These 2 patients had the same γc gene mutation.