Laboratory Parameters for 16 Pediatric Patients With SCD and Stroke Who Discontinued Chronic Transfusions and Began Oral HU Therapy to Prevent Stroke Recurrence
| Patient No. . | HU Therapy (mo) . | HU Dose (mg/kg/d) . | Hb (g/dL) . | MCV (fL) . | HbF (%) . | F Cells (%) . | Phlebotomy . | Ferritin (ng/mL) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| mo . | Total mL . | mL/kg . | Initial . | Latest . | |||||||
| 1 | 52 | 32.7 | 8.6 | 102 | 15.7 | 69.9 | 45 | 19,562 | 322 | 8,830 | 2,962 |
| 2 | 38 | 19.9 | 8.6 | 122 | 28.1 | 90.3 | 35 | 15,030 | 405 | 2,628 | 419 |
| 3 | 37 | 26.4 | 10.3 | 116 | 29.6 | 95.0 | ND | ND | ND | 560 | 225 |
| 4 | 36 | 29.9 | 10.5 | 107 | 31.2 | 95.8 | 19 | 7,412 | 282 | 2,153 | 90 |
| 5 | 33 | 20.1 | 10.5 | 114 | 27.9 | 89.0 | 14 | 4,460 | 90 | 1,025 | 169 |
| 6 | 27 | 19.1 | 10.1 | 116 | 20.6 | 85.0 | 27 | 17,090 | 326 | 5,950 | 1,911 |
| 7 | 23 | 28.1 | 9.0 | 100 | 11.9 | 58.7 | 20 | 8,765 | 308 | 2,631 | 235 |
| 8 | 22 | 27.0 | 10.0 | 129 | 23.6 | 88.5 | 23 | 19,825 | 306 | 4,206 | 1,326 |
| 9 | 21 | 27.8 | 8.0 | 123 | 18.3 | 78.8 | 21 | 9,590 | 261 | 7,281 | 3,161 |
| 10 | 20 | 21.8 | 8.8 | 104 | 27.8 | 90.0 | 17 | 12,695 | 272 | 2,877 | 128 |
| 11 | 16 | 20.1 | 11.9 | 112 | 22.7 | 86.3 | ND | ND | ND | 267 | 188 |
| 12 | 14 | 25.3 | 10.6 | 122 | 29.2 | 95.9 | 14 | 9,220 | 233 | 2,012 | 424 |
| 13 | 3 | 23.8 | 7.5 | 107 | 13.3 | 69.5 | 3 | 3,000 | 48 | 2,486 | 1,309 |
| 14 | 10 | 30.0 | 9.5 | 104 | 11.2 | 55.0 | 10 | 3,610 | 194 | 2,081 | 319 |
| 15 | 4 | 22.2 | 7.4 | 108 | 8.2 | 63.4 | 4 | 1,835 | 58 | 1,808 | 1,297 |
| 16 | 3 | 24.5 | 8.8 | 105 | 9.6 | 57.5 | 3 | 2,450 | 60 | 2,700 | ND |
| Patient No. . | HU Therapy (mo) . | HU Dose (mg/kg/d) . | Hb (g/dL) . | MCV (fL) . | HbF (%) . | F Cells (%) . | Phlebotomy . | Ferritin (ng/mL) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| mo . | Total mL . | mL/kg . | Initial . | Latest . | |||||||
| 1 | 52 | 32.7 | 8.6 | 102 | 15.7 | 69.9 | 45 | 19,562 | 322 | 8,830 | 2,962 |
| 2 | 38 | 19.9 | 8.6 | 122 | 28.1 | 90.3 | 35 | 15,030 | 405 | 2,628 | 419 |
| 3 | 37 | 26.4 | 10.3 | 116 | 29.6 | 95.0 | ND | ND | ND | 560 | 225 |
| 4 | 36 | 29.9 | 10.5 | 107 | 31.2 | 95.8 | 19 | 7,412 | 282 | 2,153 | 90 |
| 5 | 33 | 20.1 | 10.5 | 114 | 27.9 | 89.0 | 14 | 4,460 | 90 | 1,025 | 169 |
| 6 | 27 | 19.1 | 10.1 | 116 | 20.6 | 85.0 | 27 | 17,090 | 326 | 5,950 | 1,911 |
| 7 | 23 | 28.1 | 9.0 | 100 | 11.9 | 58.7 | 20 | 8,765 | 308 | 2,631 | 235 |
| 8 | 22 | 27.0 | 10.0 | 129 | 23.6 | 88.5 | 23 | 19,825 | 306 | 4,206 | 1,326 |
| 9 | 21 | 27.8 | 8.0 | 123 | 18.3 | 78.8 | 21 | 9,590 | 261 | 7,281 | 3,161 |
| 10 | 20 | 21.8 | 8.8 | 104 | 27.8 | 90.0 | 17 | 12,695 | 272 | 2,877 | 128 |
| 11 | 16 | 20.1 | 11.9 | 112 | 22.7 | 86.3 | ND | ND | ND | 267 | 188 |
| 12 | 14 | 25.3 | 10.6 | 122 | 29.2 | 95.9 | 14 | 9,220 | 233 | 2,012 | 424 |
| 13 | 3 | 23.8 | 7.5 | 107 | 13.3 | 69.5 | 3 | 3,000 | 48 | 2,486 | 1,309 |
| 14 | 10 | 30.0 | 9.5 | 104 | 11.2 | 55.0 | 10 | 3,610 | 194 | 2,081 | 319 |
| 15 | 4 | 22.2 | 7.4 | 108 | 8.2 | 63.4 | 4 | 1,835 | 58 | 1,808 | 1,297 |
| 16 | 3 | 24.5 | 8.8 | 105 | 9.6 | 57.5 | 3 | 2,450 | 60 | 2,700 | ND |
The %HbF and %F cells refer to the maximal values during HU therapy. The initial ferritin refers to the time that transfusions were discontinued.
Abbreviations: Hb, recent hemoglobin concentration; MCV, recent mean corpuscular volume; ND, not done.