Table 2.

Characteristics of Patients Showing a Disease Response

Patient No. Disease Day T-Cell Chimerism 100% Donor Disease Response
5  RCC  60  Regression of metastatic disease noted on CT scan day 86. CR day 110.  
6 Melanoma  14  Regression of metastatic disease noted by physical exam and confirmed on CT scan day 36.  
7  CML-CP 85  Philadelphia chromosome and RT-PCR for BCR/ABLnegative day 100.  
8  RCC  14  Regression of metastatic disease noted on CT scan day 220. CRU day 280.  
9 MDS (RAEBT)  164  Negative for recipient myeloid cells by minisatellite analysis day 185.  
10  Relapsed NHL  30 Regression of metastatic disease on CT scan day 60. CR day 100.  
12  CMML  65  Resolution of cytogenetic abnormality (20q−) and negative for recipient myeloid cells by minisatellite analysis day 83.  
13  RCC  14 Regression of metastatic disease on CT scan day 128. Disease regression ongoing on CT scan day 160.  
14  CML-CP  30 Philadelphia chromosome negative day 100. RT-PCR negative day 128.  
15  EMP  21  Resolution of paraproteinemia and regression of multiple plasmacytomas on CT scan day 60. Relapsed disease on CT scan day 100. DLI day 120. 
Patient No. Disease Day T-Cell Chimerism 100% Donor Disease Response
5  RCC  60  Regression of metastatic disease noted on CT scan day 86. CR day 110.  
6 Melanoma  14  Regression of metastatic disease noted by physical exam and confirmed on CT scan day 36.  
7  CML-CP 85  Philadelphia chromosome and RT-PCR for BCR/ABLnegative day 100.  
8  RCC  14  Regression of metastatic disease noted on CT scan day 220. CRU day 280.  
9 MDS (RAEBT)  164  Negative for recipient myeloid cells by minisatellite analysis day 185.  
10  Relapsed NHL  30 Regression of metastatic disease on CT scan day 60. CR day 100.  
12  CMML  65  Resolution of cytogenetic abnormality (20q−) and negative for recipient myeloid cells by minisatellite analysis day 83.  
13  RCC  14 Regression of metastatic disease on CT scan day 128. Disease regression ongoing on CT scan day 160.  
14  CML-CP  30 Philadelphia chromosome negative day 100. RT-PCR negative day 128.  
15  EMP  21  Resolution of paraproteinemia and regression of multiple plasmacytomas on CT scan day 60. Relapsed disease on CT scan day 100. DLI day 120. 

Abbreviations: RCC, renal cell carcinoma (metastatic); CML-CP, chronic myelogenous leukemia in chronic phase; MDS, myelodys- plastic syndrome; RAEBT, refractory anemia with excess blasts; NHL, diffuse large cell non-Hodgkin’s lymphoma (stage IV); CMML, chronic myelomonocytic leukemia; EMP, extramedullary plasmacytoma (multiple, unresectable, and treatment refractory); CR, complete response; CRU, complete response unsure; TRM, treatment-related mortality; DLI, donor lymphocyte infusion.

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