Table 4. Detection of Mutations in the... | American Society of Hematology

Table 4.

Detection of Mutations in the Intron and Exon Regions of the IκB Gene in Single HRS Cells

Case	No. of Isolated Cells	Type	No. of Ampli- ficates	No. of Mutations
Case	No. of Isolated Cells	Type	No. of Ampli- ficates	Intron	Exon
1	72	NS	22	3; del 19bp^4-150	1 (⇒ Stop)
1 (control cells)	27	NS	21	3; del 19bp^4-150	—
2	38	NS	22	3	—
3	24	NS	20	3; del 2bp	1^4-151
4	43	NS	23	6	—
5	53	NS	24	6	—
6	38	NS	24	3	—
7	45	NS	13	3	1^4-151
8	42	NS	17	1	—
9	24	MC	21	4; del 19bp^4-150	1^4-151
10	21	MC	19	6	1^4-151

Case	No. of Isolated Cells	Type	No. of Ampli- ficates	No. of Mutations
Case	No. of Isolated Cells	Type	No. of Ampli- ficates	Intron	Exon
1	72	NS	22	3; del 19bp^4-150	1 (⇒ Stop)
1 (control cells)	27	NS	21	3; del 19bp^4-150	—
2	38	NS	22	3	—
3	24	NS	20	3; del 2bp	1^4-151
4	43	NS	23	6	—
5	53	NS	24	6	—
6	38	NS	24	3	—
7	45	NS	13	3	1^4-151
8	42	NS	17	1	—
9	24	MC	21	4; del 19bp^4-150	1^4-151
10	21	MC	19	6	1^4-151

This 19 bp deletion was identical.

C to T transition at 2333 nt; as compared with the sequence published by Ito et al.20