Kinetics of LTC-IC Production in NOD/SCID Mice Transplanted With 107 Light-Density Human Fetal Liver or Cord Blood or 2 × 107 Light-Density Adult Marrow Cells Are Similar
| Time Posttransplant (wks) . | Fetal Liver . | Cord Blood . | Adult Marrow . |
|---|---|---|---|
| Input | 11,500 ± 600 | 730 ± 360 | 2,500 ± 1,100 |
| 2 | 10,600 ± 9,300 | 110 ± 50 | 50 ± 20 |
| 6 | 80,600 ± 58,100 | 1,430 ± 250 | 1,030 ± 540 |
| 8-10 | 52,000 ± 11,700 | 3,400 ± 1,150 | 720 ± 630 |
| Time Posttransplant (wks) . | Fetal Liver . | Cord Blood . | Adult Marrow . |
|---|---|---|---|
| Input | 11,500 ± 600 | 730 ± 360 | 2,500 ± 1,100 |
| 2 | 10,600 ± 9,300 | 110 ± 50 | 50 ± 20 |
| 6 | 80,600 ± 58,100 | 1,430 ± 250 | 1,030 ± 540 |
| 8-10 | 52,000 ± 11,700 | 3,400 ± 1,150 | 720 ± 630 |
Values shown are the absolute LTC-IC numbers calculated per mouse body, assuming 2 femurs and 2 tibias represent 25% of the total60 and that the CFC output per LTC-IC is the same as the LTC-IC in the suspension originally transplanted (ie, 72 for fetal liver-derived LTC-IC, from Table 2; 28 for cord blood-derived LTC-IC and 18 for adult marrow-derived LTC-IC from Hogge et al43). The fetal liver data are from the same 2 experiments shown in Fig 1. The cord blood and adult marrow data are derived from Cashman et al.42 48