Iron Absorption Values in Untransfused and Transfused trfhpx Mice
| Group . | n . | Mucosal Retention . | Mucosal Transfer . | Total Uptake . | Mucosal Transfer (%) . |
|---|---|---|---|---|---|
| (pmol/mg/10 min) . | |||||
| Untransfused | |||||
| Control | 10 | 22.2 ± 8.1 | 10.1 ± 5.4 | 32.3 ± 12.6 | 30.1 ± 10.5 |
| trfhpx | 6 | 28.4 ± 10.7 | 63.2 ± 14.4† | 91.5 ± 12.9† | 69.0 ± 11.1* |
| Transfusion of trfhpx with | |||||
| saline (×2) | 4 | 42.5 ± 10.4 | 65.3 ± 13.8 | 108 ± 10.2 | 60.4 ± 9.9 |
| trfhpxErythrocytes (×2) | 3 | 36.6 ± 14.0 | 87.8 ± 26.8 | 124 ± 41 | 70.9 ± 1.8 |
| Control erythrocytes | |||||
| (×1) | 3 | 29.9 ± 9.8 | 72.0 ± 3.4 | 102 ± 6.9 | 71.0 ± 7.4 |
| (×2) | 5 | 51.0 ± 19.0‡ | 46.4 ± 25.3 | 97.4 ± 36.8 | 46.5 ± 15.6‡ |
| (×3)1-154 | 6 | 37.8 ± 17.7 | 30.7 ± 19.01-153 | 68.5 ± 34.7 | 42.8 ± 8.41-155 |
| Group . | n . | Mucosal Retention . | Mucosal Transfer . | Total Uptake . | Mucosal Transfer (%) . |
|---|---|---|---|---|---|
| (pmol/mg/10 min) . | |||||
| Untransfused | |||||
| Control | 10 | 22.2 ± 8.1 | 10.1 ± 5.4 | 32.3 ± 12.6 | 30.1 ± 10.5 |
| trfhpx | 6 | 28.4 ± 10.7 | 63.2 ± 14.4† | 91.5 ± 12.9† | 69.0 ± 11.1* |
| Transfusion of trfhpx with | |||||
| saline (×2) | 4 | 42.5 ± 10.4 | 65.3 ± 13.8 | 108 ± 10.2 | 60.4 ± 9.9 |
| trfhpxErythrocytes (×2) | 3 | 36.6 ± 14.0 | 87.8 ± 26.8 | 124 ± 41 | 70.9 ± 1.8 |
| Control erythrocytes | |||||
| (×1) | 3 | 29.9 ± 9.8 | 72.0 ± 3.4 | 102 ± 6.9 | 71.0 ± 7.4 |
| (×2) | 5 | 51.0 ± 19.0‡ | 46.4 ± 25.3 | 97.4 ± 36.8 | 46.5 ± 15.6‡ |
| (×3)1-154 | 6 | 37.8 ± 17.7 | 30.7 ± 19.01-153 | 68.5 ± 34.7 | 42.8 ± 8.41-155 |
Homozygous mice were transfused with saline or erythrocytes from trfhpx or littermate controls. Iron absorption studies were performed 3 days after the last transfusion except for “
,” where studies were performed 5 days after the last transfusion. Data: mean ± SD for (n) experiments. Control group includes heterozygote and wild-type mice.
Percent mucosal transfer = [mucosal transfer (pmol/mg/10 min)/total mucosal uptake (pmol/mg/10 min)] × 100.
P < .007.
P < .001 as compared with the control group.
P < .04.
P < .008.
P < .001 as compared with nontransfused trfhpx mice.