In Vitro Inhibitory Profile of GI5402 Against a Range of Isolated MMPs and TACE
| . | Isolated Enzymes (Ki, nmol/L) . | ||||
|---|---|---|---|---|---|
| MMP-1 . | MMP-3 . | MMP-9 . | MMP-13 . | TACE . | |
| Geometric mean | 2.2 | 26.6 | 4.2 | 1.0 | 6.6 |
| 95% CI | 2.0-2.5 | 19.3-36.7 | 3.7-4.8 | 0.9-1.1 | 4.3-10.2 |
| n | 10 | 7 | 11 | 8 | 5 |
| . | Isolated Enzymes (Ki, nmol/L) . | ||||
|---|---|---|---|---|---|
| MMP-1 . | MMP-3 . | MMP-9 . | MMP-13 . | TACE . | |
| Geometric mean | 2.2 | 26.6 | 4.2 | 1.0 | 6.6 |
| 95% CI | 2.0-2.5 | 19.3-36.7 | 3.7-4.8 | 0.9-1.1 | 4.3-10.2 |
| n | 10 | 7 | 11 | 8 | 5 |