Patients’ Outcome After Salvage Therapy
Patient No. . | Duration of 1st Molecular Remission . | PML/RARα PCR After Salvage Therapy . | ABMT . | Duration of 2nd Molecular Remission . | Outcome . | ||
---|---|---|---|---|---|---|---|
Post-ATRA . | Post-CHT . | BM Harvest . | |||||
1 | 11 | Neg | Neg | Neg | Yes | 22+ | A & W in 2nd molecular remission |
2 | 11 | Pos | Neg | Neg | Yes | 17+ | A & W in 2nd molecular remission |
3 | 12 | Neg | Neg | Neg | Yes | 16+ | A & W in 2nd molecular remission |
4 | 2 | Neg | Neg | Neg | Yes | 13 | Hematologic relapse at 13 mo; 3rd molecular remission with ATRA/MTZ/AraC |
5 | 11 | Neg | Neg | ND | ND | 11+ | A & W in 2nd molecular remission |
6 | 3 | Neg | Neg | Neg | ND | 10+ | A & W in 2nd molecular remission |
7 | 7 | Pos | Neg | Neg | Yes | 9+ | A & W in 2nd molecular remission |
8 | 9 | Pos | Neg | ND | ND | 8+ | A & W in 2nd molecular remission |
9 | 3 | Neg | Neg | Neg | Yes | 7+ | A & W in 2nd molecular remission |
10 | 4 | Pos | Neg | Neg | Yes | 6+ | A & W in 2nd molecular remission |
11 | 3 | Neg | Neg | Neg | Yes | 6 | Hematologic relapse at 8 mo; patient is presently receiving As2O3 therapy |
12 | 25 | Pos | Neg | Neg | ND | 4+ | A & W in 2nd hematologic remission |
13 | 2 | Pos | Pos | ND | ND | — | Hematologic relapse at 10 mo; 2nd hematologic remission after As2O3 |
14 | 8 | Pos | Pos | ND | ND | — | Hemorrhagic death in remission |
Patient No. . | Duration of 1st Molecular Remission . | PML/RARα PCR After Salvage Therapy . | ABMT . | Duration of 2nd Molecular Remission . | Outcome . | ||
---|---|---|---|---|---|---|---|
Post-ATRA . | Post-CHT . | BM Harvest . | |||||
1 | 11 | Neg | Neg | Neg | Yes | 22+ | A & W in 2nd molecular remission |
2 | 11 | Pos | Neg | Neg | Yes | 17+ | A & W in 2nd molecular remission |
3 | 12 | Neg | Neg | Neg | Yes | 16+ | A & W in 2nd molecular remission |
4 | 2 | Neg | Neg | Neg | Yes | 13 | Hematologic relapse at 13 mo; 3rd molecular remission with ATRA/MTZ/AraC |
5 | 11 | Neg | Neg | ND | ND | 11+ | A & W in 2nd molecular remission |
6 | 3 | Neg | Neg | Neg | ND | 10+ | A & W in 2nd molecular remission |
7 | 7 | Pos | Neg | Neg | Yes | 9+ | A & W in 2nd molecular remission |
8 | 9 | Pos | Neg | ND | ND | 8+ | A & W in 2nd molecular remission |
9 | 3 | Neg | Neg | Neg | Yes | 7+ | A & W in 2nd molecular remission |
10 | 4 | Pos | Neg | Neg | Yes | 6+ | A & W in 2nd molecular remission |
11 | 3 | Neg | Neg | Neg | Yes | 6 | Hematologic relapse at 8 mo; patient is presently receiving As2O3 therapy |
12 | 25 | Pos | Neg | Neg | ND | 4+ | A & W in 2nd hematologic remission |
13 | 2 | Pos | Pos | ND | ND | — | Hematologic relapse at 10 mo; 2nd hematologic remission after As2O3 |
14 | 8 | Pos | Pos | ND | ND | — | Hemorrhagic death in remission |
Abbreviations: ABMT, autologous bone marrow transplantation; ND, not done; A & W, alive and well; CHT, chemotherapy.