Cytogenetic and FISH Analyses
| Pt No. . | Transplant Type . | Pretransplant Cytogenetics . | Posttransplant Cytogenetics (at time of MDS Diagnosis) . | FISH Marker . | Abnormal Cells Pre-HDC (%) . |
|---|---|---|---|---|---|
| 1 | ABMT | Not done | 45,XY,t(5;11)(q31q13), −7, −11, +mar[13] | −7 | 35 |
| −11 | 46 | ||||
| 2 | PBSC | Not done | 45,XX, inv(3)(q21q27), −7 [20] | −7 | 30 |
| 3 | ABMT | Not done | 45,XY,del(3)(q21q25), −5,del(7)(q11.2q34), add(13)(p11.2), add(17)(q11.2), del(20)(q11.2), −21, −22, +mar,+r[4]/44, idem,−3 [2]/46,XY [2] | del(5)(q31) | 29 |
| 4 | ABMT | Not done | 46,XY, del(5)(q15q31) [5]/ 46,XY, del(5)(q11.2q35)[19]/45,XY add(7)(q11.2), −13 [2] | del(5)(q31) | 39 |
| 5 | ABMT | 46,XX[16] | 46,XX, +der(12)t(?;12) (12;11) (?p11.2q15q21) [17]/48,XX, +8, +8[3]/ 46,XX [4] | +8 | 6 |
| 6 | ABMT | Not done | 44,X, add(X)(q26), t(3;4)(p23;q14), −5, t(6;18)(p21;q12), −11, der(14)t(5;14) q11.2q33;p11),−16,−17, add(20)(q13), add(21)(q22), +mar,+dms [4]/46,X, add(X)(q26), del(1)(p22p32), t(3;4)(p23;p14), −5, t(6;18)(p21;q12), +8, −11, der(14)t(5;14)(q11.2q33;p11), −17, +add(20)(q13), add(21)(q22), +mar, +dms [5]/46,XX [11] | +8 | 20 |
| 7 | ABMT | 46,XY[20] | 47,XY,del(3)(q13q28),+8[20] | +8 | 5 |
| 8 | Purged ABMT | Not done | 45,XX,der(6)t(3;6)(q21;q15),−7[19]/ 46,XX[10] | −7 | 41 |
| 9 | ABMT | 46,XX[15] | 45,XX,−6,−21,+mar,[4]/ 46,idem,del(9)(q22)[16] | −21 | 11 |
| 10 | CD34 + PBSC | Not done | 45,XX,del(3)(p25p21),−5, add(7)(p15), del(9)(p13p24), −15,+mar[20] | del(5)(q31) | 5 |
| 11 | ABMT/PBSCT | Not done | 46,XX,del(5)(q31)[20] | del(5)(q31) | 23 |
| 12 | ABMT | 46,XY[20] | 45,XY,−3,−5,−6,add(6)(p21),−7,−15, +mar1, +mar2, +mar3, +mar4, +mar5[7]/ 45,Y,−X, add(1)(p34), −5, del(5)(q13q31),−6,−7,−8,−9, del(10)(p13), der(11)t(5;11) (q11.2;p15), add(16)(p13.1), +mar1, +mar2, +mar3, +mar4, +mar5[3]/ 46,XY[10] | del(5)(q31) −7 | 27 7 |
| Pt No. . | Transplant Type . | Pretransplant Cytogenetics . | Posttransplant Cytogenetics (at time of MDS Diagnosis) . | FISH Marker . | Abnormal Cells Pre-HDC (%) . |
|---|---|---|---|---|---|
| 1 | ABMT | Not done | 45,XY,t(5;11)(q31q13), −7, −11, +mar[13] | −7 | 35 |
| −11 | 46 | ||||
| 2 | PBSC | Not done | 45,XX, inv(3)(q21q27), −7 [20] | −7 | 30 |
| 3 | ABMT | Not done | 45,XY,del(3)(q21q25), −5,del(7)(q11.2q34), add(13)(p11.2), add(17)(q11.2), del(20)(q11.2), −21, −22, +mar,+r[4]/44, idem,−3 [2]/46,XY [2] | del(5)(q31) | 29 |
| 4 | ABMT | Not done | 46,XY, del(5)(q15q31) [5]/ 46,XY, del(5)(q11.2q35)[19]/45,XY add(7)(q11.2), −13 [2] | del(5)(q31) | 39 |
| 5 | ABMT | 46,XX[16] | 46,XX, +der(12)t(?;12) (12;11) (?p11.2q15q21) [17]/48,XX, +8, +8[3]/ 46,XX [4] | +8 | 6 |
| 6 | ABMT | Not done | 44,X, add(X)(q26), t(3;4)(p23;q14), −5, t(6;18)(p21;q12), −11, der(14)t(5;14) q11.2q33;p11),−16,−17, add(20)(q13), add(21)(q22), +mar,+dms [4]/46,X, add(X)(q26), del(1)(p22p32), t(3;4)(p23;p14), −5, t(6;18)(p21;q12), +8, −11, der(14)t(5;14)(q11.2q33;p11), −17, +add(20)(q13), add(21)(q22), +mar, +dms [5]/46,XX [11] | +8 | 20 |
| 7 | ABMT | 46,XY[20] | 47,XY,del(3)(q13q28),+8[20] | +8 | 5 |
| 8 | Purged ABMT | Not done | 45,XX,der(6)t(3;6)(q21;q15),−7[19]/ 46,XX[10] | −7 | 41 |
| 9 | ABMT | 46,XX[15] | 45,XX,−6,−21,+mar,[4]/ 46,idem,del(9)(q22)[16] | −21 | 11 |
| 10 | CD34 + PBSC | Not done | 45,XX,del(3)(p25p21),−5, add(7)(p15), del(9)(p13p24), −15,+mar[20] | del(5)(q31) | 5 |
| 11 | ABMT/PBSCT | Not done | 46,XX,del(5)(q31)[20] | del(5)(q31) | 23 |
| 12 | ABMT | 46,XY[20] | 45,XY,−3,−5,−6,add(6)(p21),−7,−15, +mar1, +mar2, +mar3, +mar4, +mar5[7]/ 45,Y,−X, add(1)(p34), −5, del(5)(q13q31),−6,−7,−8,−9, del(10)(p13), der(11)t(5;11) (q11.2;p15), add(16)(p13.1), +mar1, +mar2, +mar3, +mar4, +mar5[3]/ 46,XY[10] | del(5)(q31) −7 | 27 7 |