TNFβ-Deficient Mice Did Not Develop Skin Vasculitis But Developed Glomerulonephritis
| TNFαβ . | 6-19 . | No. . | Serum IgG3 (mg/mL)4-150 . | Ear Lesions . | Kidney Lesions . |
|---|---|---|---|---|---|
| +/+ | + | 6 | 6.33 ± 0.79 | 4/6 | 6/6 |
| −/− | + | 5 | 6.46 ± 0.61 | 0/5 | 5/5 |
| TNFαβ . | 6-19 . | No. . | Serum IgG3 (mg/mL)4-150 . | Ear Lesions . | Kidney Lesions . |
|---|---|---|---|---|---|
| +/+ | + | 6 | 6.33 ± 0.79 | 4/6 | 6/6 |
| −/− | + | 5 | 6.46 ± 0.61 | 0/5 | 5/5 |
Mice were inoculated with 6-19 hybridoma cells as described in Table 1.
Serum levels of IgG3 (mean ± SD) were determined at time of death.