Outcome of Induction Chemotherapy
| . | Group A . | Group B . | All PEG-rHuMGDF Patients . | Placebo . | ||
|---|---|---|---|---|---|---|
| PEG-rHuMGDF 2.5 μg/kg/d to Target . | PEG-rHuMGDF 5 μg/kg/d to Target . | PEG-rHuMGDF 2.5 μg/kg/d Day 8 . | PEG-rHuMGDF 2.5 μg/kg/d Days 8 to 14 . | |||
| Induction 1 | ||||||
| No. of patients | 24 | 24 | 12 | 14 | 74 | 34 |
| Complete remission | 16 | 13 | 8 | 7 | 44 | 21 |
| Persistant disease | 8 | 10 | 3 | 6 | 27 | 9 |
| Induction 1 deaths | 0 | 1 | 1 | 0 | 2 | 4 |
| Remission rate after induction 1 | 67% | 54% | 67% | 50% | 59% | 62% |
| Induction 2 | ||||||
| No. of patients | 7 | 9 | 2 | 4 | 22 | 9 |
| Complete remission | 3 | 4 | 1 | 2 | 10 | 7 |
| Persistant disease | 4 | 4 | 0 | 2 | 10 | 2 |
| Not assessed | 0 | 1 | 1 | 0 | 2 | 0 |
| Remission rate after induction 2 | 43% | 44% | 50% | 50% | 45% | 78% |
| Overall remission rate | 79% | 71% | 75% | 64% | 73% | 82% |
| . | Group A . | Group B . | All PEG-rHuMGDF Patients . | Placebo . | ||
|---|---|---|---|---|---|---|
| PEG-rHuMGDF 2.5 μg/kg/d to Target . | PEG-rHuMGDF 5 μg/kg/d to Target . | PEG-rHuMGDF 2.5 μg/kg/d Day 8 . | PEG-rHuMGDF 2.5 μg/kg/d Days 8 to 14 . | |||
| Induction 1 | ||||||
| No. of patients | 24 | 24 | 12 | 14 | 74 | 34 |
| Complete remission | 16 | 13 | 8 | 7 | 44 | 21 |
| Persistant disease | 8 | 10 | 3 | 6 | 27 | 9 |
| Induction 1 deaths | 0 | 1 | 1 | 0 | 2 | 4 |
| Remission rate after induction 1 | 67% | 54% | 67% | 50% | 59% | 62% |
| Induction 2 | ||||||
| No. of patients | 7 | 9 | 2 | 4 | 22 | 9 |
| Complete remission | 3 | 4 | 1 | 2 | 10 | 7 |
| Persistant disease | 4 | 4 | 0 | 2 | 10 | 2 |
| Not assessed | 0 | 1 | 1 | 0 | 2 | 0 |
| Remission rate after induction 2 | 43% | 44% | 50% | 50% | 45% | 78% |
| Overall remission rate | 79% | 71% | 75% | 64% | 73% | 82% |
Remission rate odds ratio (all PEG-rHuMGDF patients vplacebo patients). Induction 1: 0.91 (0.40, 2.09); Induction 2: 0.23 (0.04, 1.35).