Results of Antibody Screening With the Indirect GIFT Test and a Panel of Donor Granulocytes
| . | Primary AIN n = 21 . | Secondary AIN n = 7 . |
|---|---|---|
| Antibody specificity* | ||
| NA1 | 16 | 0 |
| NA2 | 2 | 0 |
| FcγRIIIb | 1† | 7 |
| Inconclusive | 2‡ | 0 |
| . | Primary AIN n = 21 . | Secondary AIN n = 7 . |
|---|---|---|
| Antibody specificity* | ||
| NA1 | 16 | 0 |
| NA2 | 2 | 0 |
| FcγRIIIb | 1† | 7 |
| Inconclusive | 2‡ | 0 |
The observed difference in antibody specificity between children with primary AIN (NA-specific) or secondary AIN (pan-FcγRIIIb) was highly significant. Fisher’s exact test: P < .01.
Further analysis showed the presence of NA1, FcγRIIIb and CD11a antibodies.
The MAIGA showed the presence of NA1 antibodies in 1 of these sera and NA1 and NA2 reactivity in the other serum.