LAD Syndromes
| . | LAD I* . | LAD II . |
|---|---|---|
| Clinical manifestations | ||
| Recurrent severe infections | Frequent | Not observed |
| Neutrophilia | ||
| Basal | + | ++ |
| With infections | +++ | ++ |
| Periodontitis | Common | Marked |
| Skin infections | Common | Not observed |
| Delayed separation of the umbilical cord | Common | Not observed |
| Developmental abnormalities | None | Marked |
| Laboratory findings | ||
| CD18 expression | Marked decrease or absent | Normal |
| SLeX expression | Normal | Absent |
| Neutrophil rolling | Normal | Marked decrease |
| Neutrophil firm adherence | Marked decrease | Normal |
| T- and B-cell function | Decreased | Normal |
| . | LAD I* . | LAD II . |
|---|---|---|
| Clinical manifestations | ||
| Recurrent severe infections | Frequent | Not observed |
| Neutrophilia | ||
| Basal | + | ++ |
| With infections | +++ | ++ |
| Periodontitis | Common | Marked |
| Skin infections | Common | Not observed |
| Delayed separation of the umbilical cord | Common | Not observed |
| Developmental abnormalities | None | Marked |
| Laboratory findings | ||
| CD18 expression | Marked decrease or absent | Normal |
| SLeX expression | Normal | Absent |
| Neutrophil rolling | Normal | Marked decrease |
| Neutrophil firm adherence | Marked decrease | Normal |
| T- and B-cell function | Decreased | Normal |
Adapted and reprinted from Etzioni et al8in Ochs HD, Smith CIE, Puck JM (eds): Primary Immunodeficiency Diseases: A Molecular and Genetic Approach. New York, NY, Oxford, 1999.
Severe phenotype.