Summary of LA Characteristics and Patient Histories
| Patient No. . | Sex . | Age (yrs) . | Plasma KCT Ratio* . | Serum ACA† (U/mL) . | ANA . | dsDNA‡ . | Platelet Count (×109/L) . | ELISA Reactivity . | History of Thrombosis . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IgG . | IgM . | II1-153 . | β2GP11-155 . | ||||||||
| Control | 2 F, 3 M | 25-37 | ≤1.1 | ≤2.8 | ≤5.8 | — | — | — | − | − | Nil |
| LA1 | M | 25 | 1.5 | 8.5 | 3.4 | 1:640 | + | 136 | − | − | DVT |
| LA2 | F | 32 | 2.5 | 200 | 47.4 | 1:360 | − | 82-111 | − | + | Nonhemorrhagic CVA |
| Atrial appendage thrombus | |||||||||||
| LA3 | F | 17 | 1.8 | 62 | 9.3 | — | − | 124 | − | − | DVT and PE |
| LA4 | F | 50 | 1.3 | 80 | 13.1 | — | − | ND | + | + | Nonhemorrhagic CVA |
| LA5 | F | 14 | >2 | 58 | 31 | 1:2,560 | + | 254 | + | − | Hemorrhage and menorrhagia |
| LA6 | M | 62 | 2.1 | 1.5 | 39 | 1:80 | ND | 114-123 | − | − | AMI 8 yrs before |
| LA7 | M | 32 | 1.9 | ND | ND | ND | ND | 232 | + | − | Axillary vein thrombus |
| Patient No. . | Sex . | Age (yrs) . | Plasma KCT Ratio* . | Serum ACA† (U/mL) . | ANA . | dsDNA‡ . | Platelet Count (×109/L) . | ELISA Reactivity . | History of Thrombosis . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IgG . | IgM . | II1-153 . | β2GP11-155 . | ||||||||
| Control | 2 F, 3 M | 25-37 | ≤1.1 | ≤2.8 | ≤5.8 | — | — | — | − | − | Nil |
| LA1 | M | 25 | 1.5 | 8.5 | 3.4 | 1:640 | + | 136 | − | − | DVT |
| LA2 | F | 32 | 2.5 | 200 | 47.4 | 1:360 | − | 82-111 | − | + | Nonhemorrhagic CVA |
| Atrial appendage thrombus | |||||||||||
| LA3 | F | 17 | 1.8 | 62 | 9.3 | — | − | 124 | − | − | DVT and PE |
| LA4 | F | 50 | 1.3 | 80 | 13.1 | — | − | ND | + | + | Nonhemorrhagic CVA |
| LA5 | F | 14 | >2 | 58 | 31 | 1:2,560 | + | 254 | + | − | Hemorrhage and menorrhagia |
| LA6 | M | 62 | 2.1 | 1.5 | 39 | 1:80 | ND | 114-123 | − | − | AMI 8 yrs before |
| LA7 | M | 32 | 1.9 | ND | ND | ND | ND | 232 | + | − | Axillary vein thrombus |
Abbreviations: ND, not determined; ANA, antibodies to nuclear antigens.
Plasma KCT ratio.14
Serum ACA.14
Antibodies to dsDNA.
Reactivity against plastic-adsorbed phosphatidylserine in the presence of prothrombin.13 The same reactivity was observed against plastic-adsorbed prothrombin.13
Reactivity against plastic-adsorbed β2-GP1.13