Frequency of MDR1, LRP, MRP1, Functional Efflux, and CD34 Expression Among 352 Previously Untreated AML Patients Under Age 70
| Parameter . | Intensity . | No. . | Percent . |
|---|---|---|---|
| MDR1 (MRK16) | Bright (D ≥ 0.30) | 64 | 18 |
| Moderate (0.20 ≤ D < 0.30) | 35 | 10 | |
| Dim (0.15 ≤ D < 0.20) | 24 | 7 | |
| Negative (D < 0.15) | 228 | 65 | |
| MDR1 (MM4.17) | Bright (D ≥ 0.30) | 89 | 25 |
| Moderate (0.20 ≤ D < 0.30) | 37 | 11 | |
| Dim (0.15 ≤ D < 0.20) | 25 | 7 | |
| Negative (D < 0.15) | 200 | 57 | |
| LRP56 | Positive (D ≥ 0.25) | 138 | 43 |
| Negative (D < 0.25) | 180 | 57 | |
| MRP1 | Positive (D ≥ 0.20) | 32 | 10 |
| Negative (D < 0.20) | 289 | 90 | |
| CsA inhibited efflux | Bright (D ≥ 0.40) | 87 | 28 |
| (DiOC2) | Moderate (0.25 ≤ D < 0.40) | 43 | 14 |
| Dim (0.20 ≤ D < 0.25) | 12 | 4 | |
| Negative (D < 0.20) | 172 | 55 | |
| CsA inhibited efflux | Bright (D ≥ 0.40) | 70 | 22 |
| (Rh123) | Moderate (0.25 ≤ D < 0.40) | 39 | 12 |
| Dim (0.20 ≤ D < 0.25) | 12 | 4 | |
| Negative (D < 0.20) | 197 | 62 | |
| CD34 | Positive (all blasts) | 134 | 38 |
| Positive (blast subset) | 70 | 20 | |
| Negative | 147 | 42 |
| Parameter . | Intensity . | No. . | Percent . |
|---|---|---|---|
| MDR1 (MRK16) | Bright (D ≥ 0.30) | 64 | 18 |
| Moderate (0.20 ≤ D < 0.30) | 35 | 10 | |
| Dim (0.15 ≤ D < 0.20) | 24 | 7 | |
| Negative (D < 0.15) | 228 | 65 | |
| MDR1 (MM4.17) | Bright (D ≥ 0.30) | 89 | 25 |
| Moderate (0.20 ≤ D < 0.30) | 37 | 11 | |
| Dim (0.15 ≤ D < 0.20) | 25 | 7 | |
| Negative (D < 0.15) | 200 | 57 | |
| LRP56 | Positive (D ≥ 0.25) | 138 | 43 |
| Negative (D < 0.25) | 180 | 57 | |
| MRP1 | Positive (D ≥ 0.20) | 32 | 10 |
| Negative (D < 0.20) | 289 | 90 | |
| CsA inhibited efflux | Bright (D ≥ 0.40) | 87 | 28 |
| (DiOC2) | Moderate (0.25 ≤ D < 0.40) | 43 | 14 |
| Dim (0.20 ≤ D < 0.25) | 12 | 4 | |
| Negative (D < 0.20) | 172 | 55 | |
| CsA inhibited efflux | Bright (D ≥ 0.40) | 70 | 22 |
| (Rh123) | Moderate (0.25 ≤ D < 0.40) | 39 | 12 |
| Dim (0.20 ≤ D < 0.25) | 12 | 4 | |
| Negative (D < 0.20) | 197 | 62 | |
| CD34 | Positive (all blasts) | 134 | 38 |
| Positive (blast subset) | 70 | 20 | |
| Negative | 147 | 42 |