Table 2. Currently Identified Antigenic... | American Society of Hematology

Table 2.

Currently Identified Antigenic Peptides Expressed by MAGE-type Genes

Gene	HLA	Antigenic Peptide	Position in Protein	Predicted Frequency (%)	Reference
MAGE-A1	A1	EADPTGHSY	161-169	8	32
	Cw16	SAYGEPRKL	230-238	2	32
MAGE-A2	A2	KMVELVHFL	112-120	10	33
	A2	YLQLVFGIEV	157-166	10	33
MAGE-A3	A1	EVDPIGHLY	168-176	8	32
	A2	KVAELVHFL	112-120	16	34
	A2	FLWGPRALV	271-279	16	32
	A24	IMPKAGLLI	195-203	6	35
	B44	MEVDPIGHLY	167-176	7	32
MAGE-A12	A2	FLWGPRALV	271-279	8	^*
BAGE	Cw16	AARAVFLAL	2-10	1	32
GAGE-1/2	Cw6	YRPRPRRY	9-16	7	32
PRAME	A24	LYVDSLFFL	301-309	10	19
NY-ESO-1	A2	QLSLLMWITQCFL^†	155-167	18	36
	A31	ASGPGGGAPR	53-62	2	37
		LAAQERRVPR	18-27^‡	2	37

Gene	HLA	Antigenic Peptide	Position in Protein	Predicted Frequency (%)	Reference
MAGE-A1	A1	EADPTGHSY	161-169	8	32
	Cw16	SAYGEPRKL	230-238	2	32
MAGE-A2	A2	KMVELVHFL	112-120	10	33
	A2	YLQLVFGIEV	157-166	10	33
MAGE-A3	A1	EVDPIGHLY	168-176	8	32
	A2	KVAELVHFL	112-120	16	34
	A2	FLWGPRALV	271-279	16	32
	A24	IMPKAGLLI	195-203	6	35
	B44	MEVDPIGHLY	167-176	7	32
MAGE-A12	A2	FLWGPRALV	271-279	8	^*
BAGE	Cw16	AARAVFLAL	2-10	1	32
GAGE-1/2	Cw6	YRPRPRRY	9-16	7	32
PRAME	A24	LYVDSLFFL	301-309	10	19
NY-ESO-1	A2	QLSLLMWITQCFL^†	155-167	18	36
	A31	ASGPGGGAPR	53-62	2	37
		LAAQERRVPR	18-27^‡	2	37

The predicted frequency of these antigens in advanced myelomas (stage III or plasma cell leukemia) is obtained by multiplying the probability of having the corresponding gene expressed by the myeloma and the prevalence of the HLA allele in the Caucasian population.

Identical to MAGE-A3(271-279) peptide.

†

Optimal antigenic sequence remains to be determined.

‡

Alternative open reading frame.

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