Table 3.

In Vitro MDR Variables Influencing Achievement of CR (using the threshold of positivity)

Variables3-150 (thresholds of positivity)3-151Response to Treatment P Value3-152
No. % CR
Pgp expression (1.3)  
 Positive 31  51  .02  
 Negative  29  79  
MRP1 expression (1.4)  
 Positive  20  45  .02  
 Negative  40 75  
Modulatory effect of CsA on calcein-AM uptake (1.39) 
 Positive  14  42  .03  
 Negative  26  76 
Modulatory effect of probenecid on calcein-AM uptake (1.28) 
 Positive  11  36  .02  
 Negative  29  75 
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41)  
 Positive  18  33  .0001  
 Negative 22  90 
Variables3-150 (thresholds of positivity)3-151Response to Treatment P Value3-152
No. % CR
Pgp expression (1.3)  
 Positive 31  51  .02  
 Negative  29  79  
MRP1 expression (1.4)  
 Positive  20  45  .02  
 Negative  40 75  
Modulatory effect of CsA on calcein-AM uptake (1.39) 
 Positive  14  42  .03  
 Negative  26  76 
Modulatory effect of probenecid on calcein-AM uptake (1.28) 
 Positive  11  36  .02  
 Negative  29  75 
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41)  
 Positive  18  33  .0001  
 Negative 22  90 
F3-150

None of the other in vitro resistance parameters, Mvp/LRP expression, LC50 DNR, LC50 etoposide, or LC50 Ara-C, had prognostic significance.

F3-151

The thresholds of positivity were defined in Figs 2, 3, and 5.

F3-152

Using χ2 test.

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