In Vitro MDR Variables Influencing Achievement of CR (using the threshold of positivity)
Variables3-150 (thresholds of positivity)3-151 . | Response to Treatment . | P Value3-152 . | |
---|---|---|---|
No. . | % CR . | ||
Pgp expression (1.3) | |||
Positive | 31 | 51 | .02 |
Negative | 29 | 79 | |
MRP1 expression (1.4) | |||
Positive | 20 | 45 | .02 |
Negative | 40 | 75 | |
Modulatory effect of CsA on calcein-AM uptake (1.39) | |||
Positive | 14 | 42 | .03 |
Negative | 26 | 76 | |
Modulatory effect of probenecid on calcein-AM uptake (1.28) | |||
Positive | 11 | 36 | .02 |
Negative | 29 | 75 | |
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41) | |||
Positive | 18 | 33 | .0001 |
Negative | 22 | 90 |
Variables3-150 (thresholds of positivity)3-151 . | Response to Treatment . | P Value3-152 . | |
---|---|---|---|
No. . | % CR . | ||
Pgp expression (1.3) | |||
Positive | 31 | 51 | .02 |
Negative | 29 | 79 | |
MRP1 expression (1.4) | |||
Positive | 20 | 45 | .02 |
Negative | 40 | 75 | |
Modulatory effect of CsA on calcein-AM uptake (1.39) | |||
Positive | 14 | 42 | .03 |
Negative | 26 | 76 | |
Modulatory effect of probenecid on calcein-AM uptake (1.28) | |||
Positive | 11 | 36 | .02 |
Negative | 29 | 75 | |
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41) | |||
Positive | 18 | 33 | .0001 |
Negative | 22 | 90 |