Clinical Features of Younger and Older CLL Patients
| . | CLL ≤55 yrs . | CLL >55 yrs . | P Value . |
|---|---|---|---|
| No. of patients | 204 | 807 | — |
| Median age in yrs (range) | 48.7 (31-55) | 66.7 (56-91) | — |
| Male/female ratio | 2.85 | 1.29 | <.0001 |
| Median no. of lymphocytes (109/L) | 29.7 | 27.6 | NS |
| Rai’s stages | |||
| 0 | 39% | 43% | |
| I-II | 52% | 45% | NS |
| III-IV | 9% | 12% | |
| Binet’s stages | |||
| A | 75% | 80% | |
| B | 17% | 11% | NS |
| C | 8% | 9% | |
| Smouldering disease | 34% | 33% | NS |
| BM histology | |||
| Nondiffuse | 74% | 72% | NS |
| Diffuse | 26% | 28% | |
| LDT | |||
| >12 mo | 54% | 59% | |
| ≤12 mo | 16% | 16% | NS |
| AD | |||
| ≤12 mo | 30% | 25% |
| . | CLL ≤55 yrs . | CLL >55 yrs . | P Value . |
|---|---|---|---|
| No. of patients | 204 | 807 | — |
| Median age in yrs (range) | 48.7 (31-55) | 66.7 (56-91) | — |
| Male/female ratio | 2.85 | 1.29 | <.0001 |
| Median no. of lymphocytes (109/L) | 29.7 | 27.6 | NS |
| Rai’s stages | |||
| 0 | 39% | 43% | |
| I-II | 52% | 45% | NS |
| III-IV | 9% | 12% | |
| Binet’s stages | |||
| A | 75% | 80% | |
| B | 17% | 11% | NS |
| C | 8% | 9% | |
| Smouldering disease | 34% | 33% | NS |
| BM histology | |||
| Nondiffuse | 74% | 72% | NS |
| Diffuse | 26% | 28% | |
| LDT | |||
| >12 mo | 54% | 59% | |
| ≤12 mo | 16% | 16% | NS |
| AD | |||
| ≤12 mo | 30% | 25% |
Abbreviation: NS, not significant.