Frequency of the NQO1 Polymorphism in 45 Primary and Therapy-Related Myeloid Leukemia Patients With Clonal Abnormalities of Chromosomes 5 and/or 7
| NQO1 Genes . | No. Observed (%) . | No. Expected (%) . | P . |
|---|---|---|---|
| 2 Wild-type alleles | 21 (47) | 27.58 (61) | |
| Heterozygous | 17 (38) | 15.25 (34) | .002 |
| Homozygous | 7 (16) | 2.16 (5) |
| NQO1 Genes . | No. Observed (%) . | No. Expected (%) . | P . |
|---|---|---|---|
| 2 Wild-type alleles | 21 (47) | 27.58 (61) | |
| Heterozygous | 17 (38) | 15.25 (34) | .002 |
| Homozygous | 7 (16) | 2.16 (5) |
The observed frequency of the mutant allele (0.34) was increased approximately 1.6-fold within this group of 45 patients (P = .002). Among 33 patients with balanced translocations, the mutant allele frequency was 0.23, approximately what would be expected.