Specific Clonal Cytogenetic Rearrangements and the NQO1 Polymorphism
| Cytogenetics . | No. of Patients . | No. (%) of Patients With . | ||
|---|---|---|---|---|
| Wild-type Alleles . | Heterozygous Mutation . | Homozygous Mutation . | ||
| Abnormal no. 5 | 13 | 8 (62) | 2 (15) | 3 (23) |
| Abnormal no. 7 | 16 | 4 (25) | 9 (56) | 3 (19) |
| Abnormal no. 5 & 7 | 16 | 9 (56) | 6 (38) | 1 (6) |
| t(11q23) or t(21q22) | 14 | 10 (71) | 4 (29) | 0 |
| inv(16) or t(15;17) | 10 | 3 (30) | 7 (70) | 0 |
| t(9;22) | 9 | 5 (56) | 4 (44) | 0 |
| Other abnormality | 14 | 6 (43) | 8 (57) | 0 |
| Normal | 15 | 8 (53) | 6 (40) | 1 (5) |
| Total numbers | 1073-150 | 53 (50) | 46 (43) | 8 (7) |
| Cytogenetics . | No. of Patients . | No. (%) of Patients With . | ||
|---|---|---|---|---|
| Wild-type Alleles . | Heterozygous Mutation . | Homozygous Mutation . | ||
| Abnormal no. 5 | 13 | 8 (62) | 2 (15) | 3 (23) |
| Abnormal no. 7 | 16 | 4 (25) | 9 (56) | 3 (19) |
| Abnormal no. 5 & 7 | 16 | 9 (56) | 6 (38) | 1 (6) |
| t(11q23) or t(21q22) | 14 | 10 (71) | 4 (29) | 0 |
| inv(16) or t(15;17) | 10 | 3 (30) | 7 (70) | 0 |
| t(9;22) | 9 | 5 (56) | 4 (44) | 0 |
| Other abnormality | 14 | 6 (43) | 8 (57) | 0 |
| Normal | 15 | 8 (53) | 6 (40) | 1 (5) |
| Total numbers | 1073-150 | 53 (50) | 46 (43) | 8 (7) |
Three of the 104 patients had complex karyotypes with 2 recurring abnormalities, and each is included twice in this table. Two had wild-type alleles for NQO1: an Hispanic man with t-AML had del(5q) and t(3;21), and a Caucasian woman with AML after MDS had abnormalities of no. 5 and 7 and t(11;16)(q23;p13). One patient was heterozygous for the NQO1 polymorphism: a Caucasian man with AML de novo had inv(16) and t(11;21)(q13;q22).