Table 1. Busulfan CL/F * in Underweight... | American Society of Hematology

Table 1.

Busulfan CL/F^* in Underweight (BMI <18 kg/m²), Normal (BMI = 18 to 26.9 kg/m²), Obese (BMI = 27 to 35 kg/m²), and Severely Obese Patients (BMI >35 kg/m²)

	Underweight	Normal			Obese			Severely Obese
	Mean	Male	Female	Mean	Male	Female	Mean	Mean
n	7	75	98		46	43		10
Age, years	23.2 ± 12.7	39.3 ± 12.2	41.7 ± 11.8	40.7 ± 12.0	44.2 ± 10.3	43.8 ± 9.2	44.0 ± 9.7	47.0 ± 11.6
CL/F, mL/min^†	169 ± 34	209 ± 48	175 ± 36^1-153	190 ± 45	240 ± 59	206 ± 38^1-153	223 ± 53	250 ± 47
mL/min/kg BW^†	3.84 ± 0.87	2.88 ± 0.62	2.91 ± 0.62	2.90 ± 0.62	2.60 ± 0.62	2.52 ± 0.48	2.56 ± 0.55	2.30 ± 0.51
mL/min/m² ^‡	119 ± 22	111 ± 23	106 ± 23	108 ± 23	114 ± 27	107 ± 20	110 ± 24	113 ± 26
mL/min/kg AIBW^‡	3.11 ± 0.54	2.91 ± 0.63	3.08 ± 0.63	3.01 ± 0.63	3.10 ± 0.74	3.28 ± 0.63	3.19 ± 0.69	3.41 ± 0.79

	Underweight	Normal			Obese			Severely Obese
	Mean	Male	Female	Mean	Male	Female	Mean	Mean
n	7	75	98		46	43		10
Age, years	23.2 ± 12.7	39.3 ± 12.2	41.7 ± 11.8	40.7 ± 12.0	44.2 ± 10.3	43.8 ± 9.2	44.0 ± 9.7	47.0 ± 11.6
CL/F, mL/min^†	169 ± 34	209 ± 48	175 ± 36^1-153	190 ± 45	240 ± 59	206 ± 38^1-153	223 ± 53	250 ± 47
mL/min/kg BW^†	3.84 ± 0.87	2.88 ± 0.62	2.91 ± 0.62	2.90 ± 0.62	2.60 ± 0.62	2.52 ± 0.48	2.56 ± 0.55	2.30 ± 0.51
mL/min/m² ^‡	119 ± 22	111 ± 23	106 ± 23	108 ± 23	114 ± 27	107 ± 20	110 ± 24	113 ± 26
mL/min/kg AIBW^‡	3.11 ± 0.54	2.91 ± 0.63	3.08 ± 0.63	3.01 ± 0.63	3.10 ± 0.74	3.28 ± 0.63	3.19 ± 0.69	3.41 ± 0.79

Data are mean ± SD.

†

Statistical comparisons of CL/F among different BMI categories are made in Table 2.

‡

There were no statistically significant differences in the mean CL/F expressed relative to BSA or AIBW among underweight, normal, obese, and severely obese patients.

F1-153

Denotes a statistically significant difference (P < .05) for the mean CL/F in males and females within a BMI category.

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