Table 1. LTC-IC Expansion in... | American Society of Hematology

Table 1.

LTC-IC Expansion in AFT024/Flt3-L/SCF/IL-7 Cultures Is Due to LTC-IC Net-Conservation and Net-Proliferation

Exp.	Day 0 LTC-IC (%)	LTC-IC at Week 4						Fold Expansion
		Conserved LTC-IC	No Proliferation		Proliferation		Total LTC-IC
		Conserved LTC-IC	1 LTC-IC	2 LTC-IC	3 LTC-IC	4 LTC-IC	Total LTC-IC
1	6.9%	11/132^* (8.3%)	4/11^†	4/11	2/11	1/11	22/132^‡ (16.6%)	2.4
2	8.5%	13/132^* (9.8%)	8/13^†	4/13	0/13	1/13	20/132^‡ (15.2%)	1.8
3	6.8%	11/88^* (12.5%)	5/11^†	5/11	1/11	0/11	18/88^‡ (20.4%)	3.0
4	4.2%	6/88^* (6.8%)	4/6^†	1/6	0/6	1/6	10/88^‡ (11.4%)	2.7

Exp.	Day 0 LTC-IC (%)	LTC-IC at Week 4						Fold Expansion
		Conserved LTC-IC	No Proliferation		Proliferation		Total LTC-IC
		Conserved LTC-IC	1 LTC-IC	2 LTC-IC	3 LTC-IC	4 LTC-IC	Total LTC-IC
1	6.9%	11/132^* (8.3%)	4/11^†	4/11	2/11	1/11	22/132^‡ (16.6%)	2.4
2	8.5%	13/132^* (9.8%)	8/13^†	4/13	0/13	1/13	20/132^‡ (15.2%)	1.8
3	6.8%	11/88^* (12.5%)	5/11^†	5/11	1/11	0/11	18/88^‡ (20.4%)	3.0
4	4.2%	6/88^* (6.8%)	4/6^†	1/6	0/6	1/6	10/88^‡ (11.4%)	2.7

Number of single-sorted Lin⁻/34⁺/DR^dim cells that generated at least 1 secondary LTC-IC per initially plated cell.

Number of LTC-IC (per conserved LTC-IC) that did not proliferate (only 1 secondary LTC-IC).

Total number of secondary LTC-IC per single sorted Lin⁻/34⁺/DR^dim cell.