Usage of Different Jh Gene Segments in Incomplete and Complete Cross-Lineage IGH Gene Rearrangements in T-ALL as Compared With Precursor-B-ALL, Human BM Precursor-B Cells, and PB B Lymphocytes
Jh Segment . | T-ALL (n = 39) . | PrecursorB-ALL . | Human BM Precursor-B Cells . | Human PB B Lymphocytes . |
---|---|---|---|---|
Jh1 | 13% (5) | 2% | 0% | 1% |
Jh2 | 15% (6) | 2% | 4% | 0% |
Jh3 | 10% (4) | 11% | 14% | 9% |
Jh4 | 33% (13) | 32% | 32% | 53% |
Jh5 | 8% (3) | 22% | 17% | 15% |
Jh6 | 21% (8) | 32% | 33% | 22% |
Jh Segment . | T-ALL (n = 39) . | PrecursorB-ALL . | Human BM Precursor-B Cells . | Human PB B Lymphocytes . |
---|---|---|---|---|
Jh1 | 13% (5) | 2% | 0% | 1% |
Jh2 | 15% (6) | 2% | 4% | 0% |
Jh3 | 10% (4) | 11% | 14% | 9% |
Jh4 | 33% (13) | 32% | 32% | 53% |
Jh5 | 8% (3) | 22% | 17% | 15% |
Jh6 | 21% (8) | 32% | 33% | 22% |
The B-lineage data were obtained in comparable PCR-based studies by Steenbergen et al37 for precursor-B-ALL, by Raaphorst et al36 for human BM precursor-B cells, and by Yamada et al35 for human blood B lymphocytes.