Clinical and Phenotypic Characteristics of EBV+ NK Leukemia
| Case . | Diagnosis . | Age/Sex . | Peripheral Blood . | Surface Phenotypes . | Karyotypes . | Hepatosplenomegaly . | Survival (mo) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (/μL) . | LGL (% of MNC) . | CD2 . | CD3 . | CD7 . | CD16 . | CD56 . | ||||||
| 1 | NK leukemia | 18/M | 25,300 | 96% | 99.4 | 4.3 | 91.0 | 1.9 | 92.0 | 46XY | +++ | 5.0 |
| 2 | NK leukemia | 23/M | 5,300 | 98% | 98.2 | 4.4 | 79.6 | 1.1 | 88.3 | NE | +++ | 6.0 |
| 3 | NK leukemia | 75/M | 6,700 | 98% | 83.7 | 1.1 | 20.5 | 2.2 | 82.8 | +8,i17(q10) | ++ | 1.0 |
| 4 | NK leukemia | 16/F | 23,200 | 97% | 98.3 | 3.5 | 87.7 | 19.3 | 91.2 | NE | ++ | 0.5 |
| 5 | NK leukemia | 52/F | 12,600 | 98% | 96.5 | 1.5 | 2.3 | 16.1 | 96.6 | NE | ++ | 4.0 |
| 6 | NK leukemia | 65/M | 1,400 | 96% | 54.1 | 7.2 | 52.1 | 0.9 | 56.3 | 46XY | + | 1.5 |
| 7 | NK leukemia | 35/M | 12,800 | 89% | 93.4 | 6.1 | 79.0 | 3.0 | 89.8 | 46XY | +++ | 3.0 |
| 8 | Chronic NK lymphocytosis | 41/M | 5,200 | 47% | 76.5 | 21.0 | ND | 52.7 | 53.1 | NE | − | >48.0 |
| Case . | Diagnosis . | Age/Sex . | Peripheral Blood . | Surface Phenotypes . | Karyotypes . | Hepatosplenomegaly . | Survival (mo) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (/μL) . | LGL (% of MNC) . | CD2 . | CD3 . | CD7 . | CD16 . | CD56 . | ||||||
| 1 | NK leukemia | 18/M | 25,300 | 96% | 99.4 | 4.3 | 91.0 | 1.9 | 92.0 | 46XY | +++ | 5.0 |
| 2 | NK leukemia | 23/M | 5,300 | 98% | 98.2 | 4.4 | 79.6 | 1.1 | 88.3 | NE | +++ | 6.0 |
| 3 | NK leukemia | 75/M | 6,700 | 98% | 83.7 | 1.1 | 20.5 | 2.2 | 82.8 | +8,i17(q10) | ++ | 1.0 |
| 4 | NK leukemia | 16/F | 23,200 | 97% | 98.3 | 3.5 | 87.7 | 19.3 | 91.2 | NE | ++ | 0.5 |
| 5 | NK leukemia | 52/F | 12,600 | 98% | 96.5 | 1.5 | 2.3 | 16.1 | 96.6 | NE | ++ | 4.0 |
| 6 | NK leukemia | 65/M | 1,400 | 96% | 54.1 | 7.2 | 52.1 | 0.9 | 56.3 | 46XY | + | 1.5 |
| 7 | NK leukemia | 35/M | 12,800 | 89% | 93.4 | 6.1 | 79.0 | 3.0 | 89.8 | 46XY | +++ | 3.0 |
| 8 | Chronic NK lymphocytosis | 41/M | 5,200 | 47% | 76.5 | 21.0 | ND | 52.7 | 53.1 | NE | − | >48.0 |
Abbreviations: WBC, white blood cell count; LGL, large granular lymphocyte; MNC, mononuclear cell; −, negative; +, slight; ++, moderate; +++, huge; NE, no evaluable mitotic cells; ND, not done.