Lifespan and Activation of GATA-1–Deficient and Wild-Type Platelets
| Variable . | Wild-Type . | Mutant . | P . |
|---|---|---|---|
| Platelet count (×10−6/μL) | 1.16 ± 0.12 | 0.18 ± 0.03 | <.00001 |
| Spontaneous activation (%) | 23.4 ± 11.7 | 18.9 ± 4.0 | NS |
| ADP activation (%) | 33.3 ± 7.9 | 32.2 ± 6.0 | NS |
| ADP + epinephrine activation (%) | 40.4 ± 8.4 | 23.5 ± 3.7 | .01 |
| Thrombin activation (%) | 92.9 ± 2.9 | 83.4 ± 2.7 | .002 |
| Platelet lifespan (hr) | 91.4 ± 17.3 | 105.4 ± 20.5 | NS |
| Variable . | Wild-Type . | Mutant . | P . |
|---|---|---|---|
| Platelet count (×10−6/μL) | 1.16 ± 0.12 | 0.18 ± 0.03 | <.00001 |
| Spontaneous activation (%) | 23.4 ± 11.7 | 18.9 ± 4.0 | NS |
| ADP activation (%) | 33.3 ± 7.9 | 32.2 ± 6.0 | NS |
| ADP + epinephrine activation (%) | 40.4 ± 8.4 | 23.5 ± 3.7 | .01 |
| Thrombin activation (%) | 92.9 ± 2.9 | 83.4 ± 2.7 | .002 |
| Platelet lifespan (hr) | 91.4 ± 17.3 | 105.4 ± 20.5 | NS |
Platelets isolated from 4 wild-type and 4 GATA-1–deficient ΔneoΔHS adult mice were tested for in vivo lifespan and activation in response to a variety of agonists.
Abbreviation: NS, not significant.