Mean Values of Plasma Concentrations of Factor VII Protein and Activated Factor VII in Groups of Healthy Men With Different Combinations of Factor VII Genotypes
| Genotypes . | Factor VII Protein . | Covariance Analysis . | % of Phenotypic Variation . | ||
|---|---|---|---|---|---|
| No. . | % . | VIIag (ng/mL) . | |||
| [−401G/T]/[−402G/A] | |||||
| GG/AA | 13 | 7.1 | 565 ± 83 | 7.56 | 17.8 |
| GG/GA | 71 | 38.8 | 524 ± 114 | <.0001 | |
| GG/GG | 67 | 36.6 | 469 ± 101 | ||
| GT/GA | 10 | 5.5 | 409 ± 106 | ||
| GT/GG | 21 | 11.5 | 408 ± 84 | ||
| TT/GG | 1 | 0.5 | 331 | ||
| [−401G/T]/[R353Q] | |||||
| GG/RR | 151 | 82.5 | 503 ± 110 | 7.58 | 11.6 |
| GT/RR | 4 | 2.2 | 462 ± 87 | <.0001 | |
| GT/RQ | 27 | 14.8 | 400 ± 89 | ||
| TT/RQ | 1 | 0.5 | 331 | ||
| [−402G/A]/[R353Q] | |||||
| AA/RR | 13 | 7.1 | 565 ± 83 | 9.45 | 17.8 |
| GG/RR | 73 | 39.9 | 522 ± 114 | <.0001 | |
| GA/RR | 69 | 37.7 | 469 ± 100 | ||
| GG/RQ | 20 | 10.9 | 398 ± 81 | ||
| GA/RQ | 8 | 4.4 | 396 ± 110 | ||
| Genotypes | Activated Factor VII | Covariance Analysis | % of Phenotypic Variation | ||
| No. | % | VIIa (ng/mL) | |||
| [−401G/T]/[−402G/A] | |||||
| GG/AA | 13 | 7.1 | 5.8 ± 1.6 | 13.89 | 27.6 |
| GG/GG | 67 | 36.6 | 5.0 ± 1.6 | <.0001 | |
| GG/GA | 71 | 38.8 | 4.9 ± 1.5 | ||
| GT/GA | 10 | 5.5 | 3.2 ± 1.0 | ||
| GT/GG | 21 | 11.5 | 3.1 ± 0.7 | ||
| TT/GG | 1 | 0.5 | 2.6 | ||
| [−401G/T]/[R353Q] | |||||
| GG/RR | 151 | 82.5 | 5.0 ± 1.6 | 20.63 | 26.3 |
| GT/RR | 4 | 2.2 | 3.4 ± 1.0 | <.0001 | |
| GT/RQ | 27 | 14.8 | 3.1 ± 0.8 | ||
| TT/RQ | 1 | 0.5 | 2.6 | ||
| [−402G/T]/[R353Q] | |||||
| AA/RR | 13 | 7.1 | 5.8 ± 1.6 | 14.79 | 25.5 |
| GG/RR | 73 | 39.9 | 4.9 ± 1.6 | <.0001 | |
| GA/RR | 69 | 37.7 | 4.9 ± 1.5 | ||
| GG/RQ | 20 | 10.9 | 3.1 ± 0.7 | ||
| GA/RQ | 8 | 4.4 | 2.9 ± 0.9 | ||
| Genotypes . | Factor VII Protein . | Covariance Analysis . | % of Phenotypic Variation . | ||
|---|---|---|---|---|---|
| No. . | % . | VIIag (ng/mL) . | |||
| [−401G/T]/[−402G/A] | |||||
| GG/AA | 13 | 7.1 | 565 ± 83 | 7.56 | 17.8 |
| GG/GA | 71 | 38.8 | 524 ± 114 | <.0001 | |
| GG/GG | 67 | 36.6 | 469 ± 101 | ||
| GT/GA | 10 | 5.5 | 409 ± 106 | ||
| GT/GG | 21 | 11.5 | 408 ± 84 | ||
| TT/GG | 1 | 0.5 | 331 | ||
| [−401G/T]/[R353Q] | |||||
| GG/RR | 151 | 82.5 | 503 ± 110 | 7.58 | 11.6 |
| GT/RR | 4 | 2.2 | 462 ± 87 | <.0001 | |
| GT/RQ | 27 | 14.8 | 400 ± 89 | ||
| TT/RQ | 1 | 0.5 | 331 | ||
| [−402G/A]/[R353Q] | |||||
| AA/RR | 13 | 7.1 | 565 ± 83 | 9.45 | 17.8 |
| GG/RR | 73 | 39.9 | 522 ± 114 | <.0001 | |
| GA/RR | 69 | 37.7 | 469 ± 100 | ||
| GG/RQ | 20 | 10.9 | 398 ± 81 | ||
| GA/RQ | 8 | 4.4 | 396 ± 110 | ||
| Genotypes | Activated Factor VII | Covariance Analysis | % of Phenotypic Variation | ||
| No. | % | VIIa (ng/mL) | |||
| [−401G/T]/[−402G/A] | |||||
| GG/AA | 13 | 7.1 | 5.8 ± 1.6 | 13.89 | 27.6 |
| GG/GG | 67 | 36.6 | 5.0 ± 1.6 | <.0001 | |
| GG/GA | 71 | 38.8 | 4.9 ± 1.5 | ||
| GT/GA | 10 | 5.5 | 3.2 ± 1.0 | ||
| GT/GG | 21 | 11.5 | 3.1 ± 0.7 | ||
| TT/GG | 1 | 0.5 | 2.6 | ||
| [−401G/T]/[R353Q] | |||||
| GG/RR | 151 | 82.5 | 5.0 ± 1.6 | 20.63 | 26.3 |
| GT/RR | 4 | 2.2 | 3.4 ± 1.0 | <.0001 | |
| GT/RQ | 27 | 14.8 | 3.1 ± 0.8 | ||
| TT/RQ | 1 | 0.5 | 2.6 | ||
| [−402G/T]/[R353Q] | |||||
| AA/RR | 13 | 7.1 | 5.8 ± 1.6 | 14.79 | 25.5 |
| GG/RR | 73 | 39.9 | 4.9 ± 1.6 | <.0001 | |
| GA/RR | 69 | 37.7 | 4.9 ± 1.5 | ||
| GG/RQ | 20 | 10.9 | 3.1 ± 0.7 | ||
| GA/RQ | 8 | 4.4 | 2.9 ± 0.9 | ||
Values are mean ± SD. One-way analysis of covariance (with age as covariate) was performed to test whether genetic variation within the factor VII promoter was associated with differences in factor VII mass concentration (VIIag) and plasma levels of activated factor VII (VIIa).