Associations Between the −401G/T and −402G/A Polymorphisms in the Promoter Region of the Factor VII Gene Locus and Plasma Concentrations of Factor VII Protein and Activated Factor VII in Healthy Men
| −401 Genotype . | −401G/G . | −401G/T . | −401T/T . | Covariance Analysis . | % of Phenotypic Variation . |
|---|---|---|---|---|---|
| N | 151 | 31 | 1 | ||
| VIIag (ng/mL) | 503 ± 110 | 408 ± 90 | 331 | <.0001 | 11.0 |
| VIIa (ng/mL) | 5.0 ± 1.2 | 3.1 ± 0.7 | 2.6 | <.0001 | 19.1 |
| −402 Genotype | −402G/G | −402G/A | −402A/A | Covariance Analysis | % of Phenotypic Variation |
| N | 89 | 81 | 13 | ||
| VIIag (ng/mL) | 453 ± 100 | 510 ± 119 | 565 ± 83 | <.001 | 10.1 |
| VIIa (ng/mL) | 4.5 ± 1.6 | 4.7 ± 1.6 | 5.8 ± 1.6 | <.001 | 4.6 |
| −401 Genotype . | −401G/G . | −401G/T . | −401T/T . | Covariance Analysis . | % of Phenotypic Variation . |
|---|---|---|---|---|---|
| N | 151 | 31 | 1 | ||
| VIIag (ng/mL) | 503 ± 110 | 408 ± 90 | 331 | <.0001 | 11.0 |
| VIIa (ng/mL) | 5.0 ± 1.2 | 3.1 ± 0.7 | 2.6 | <.0001 | 19.1 |
| −402 Genotype | −402G/G | −402G/A | −402A/A | Covariance Analysis | % of Phenotypic Variation |
| N | 89 | 81 | 13 | ||
| VIIag (ng/mL) | 453 ± 100 | 510 ± 119 | 565 ± 83 | <.001 | 10.1 |
| VIIa (ng/mL) | 4.5 ± 1.6 | 4.7 ± 1.6 | 5.8 ± 1.6 | <.001 | 4.6 |
Values are mean ± SD. One-way analysis of covariance (with age as covariate) was performed to test whether genetic variation within the factor VII promoter was associated with differences in factor VII mass concentration (VIIag) and plasma levels of activated factor VII (VIIa). The percentage of genotype-based variation in factor VII levels was calculated according to Sing and Davignon.34