Assessment of TA-GVHD
Group4-150 . | Spleen Index (spleen wt/body wt ×1,000) . | % Donor T-cell Engraftment . | Thymic Cellularity (×107 cells) . |
---|---|---|---|
Control | 3.67 ± 0.2 (n = 6) | 0.25 ± 0.05 (n = 2) | 5.5 ± 0.9 (n = 6) |
GVHD4-151 | 18.75 ± 1.3 (n = 4) | 34.34 ± 2.2 (n = 2) | 1.2 ± 0.2 (n = 4) |
Gamma | 3.64 ± 0.4 (n = 4) | 0.53 ± 0.05 (n = 2) | 3.8 ± 0.6 (n = 4) |
PCT | 3.66 ± 0.3 (n = 4) | 0.41 ± 0.03 (n = 2) | 3.8 ± 0.6 (n = 4) |
Group4-150 . | Spleen Index (spleen wt/body wt ×1,000) . | % Donor T-cell Engraftment . | Thymic Cellularity (×107 cells) . |
---|---|---|---|
Control | 3.67 ± 0.2 (n = 6) | 0.25 ± 0.05 (n = 2) | 5.5 ± 0.9 (n = 6) |
GVHD4-151 | 18.75 ± 1.3 (n = 4) | 34.34 ± 2.2 (n = 2) | 1.2 ± 0.2 (n = 4) |
Gamma | 3.64 ± 0.4 (n = 4) | 0.53 ± 0.05 (n = 2) | 3.8 ± 0.6 (n = 4) |
PCT | 3.66 ± 0.3 (n = 4) | 0.41 ± 0.03 (n = 2) | 3.8 ± 0.6 (n = 4) |
Control, syngeneic control; GVHD, allogeneic control; Gamma, allogeneic, gamma radiation (2,500 cGy); PCT, allogeneic, S-59 (150 μmol/L) and UVA (2.1 J/cm2).
For all of the parameters the GVHD group was statistically different from the PCT, Gamma, and Control group when analyzed by Student’st-test (P > .05). Differences among the Control, PCT, and Gamma groups were not significant when analyzed by Student’st-test (P > .05). The mean values, standard error, and the number of mice used (n) is indicated for each treatment group and assay.