Recovery of Exogenous Glucocerebrosidase Activity in Different Liver Cell Types 20 Minutes After a Bolus IV Injection of pGCR to Balb/c Mice at a Dose of 40 U/kg Body Weight (approximately 680 mU/mouse)
| pGCR Measurement . | Liver Cell Type . | Total . | ||
|---|---|---|---|---|
| KC . | PC . | LEC/SC . | ||
| mU/106cells | 3.7 ± 0.8 | 3.3 ± 0.4 | 1.3 ± 1.0 | |
| Uptake normalized to 106 KC | 1 | 0.89 | 0.35 | |
| Relative diameter (surface area) | 1 | 2.3 | 0.8 | |
| Uptake normalized to surface area | 1 | 0.39 | 0.44 | |
| Cells per g liver | 1.5 × 107 | 1.15 × 108 | 4.8 × 107 | |
| mU/liver | 55 ± 13 | 385 ± 50 | 63 ± 46 | 503 ± 69 |
| % injected dose | 8.1 ± 1.8 | 56.5 ± 7.4 | 9.3 ± 6.8 | 73.9 ± 7.4 |
| % recovered dose | 11.4 ± 4.5 | 76.7 ± 5.4 | 11.8 ± 8.6 | 100 |
| pGCR Measurement . | Liver Cell Type . | Total . | ||
|---|---|---|---|---|
| KC . | PC . | LEC/SC . | ||
| mU/106cells | 3.7 ± 0.8 | 3.3 ± 0.4 | 1.3 ± 1.0 | |
| Uptake normalized to 106 KC | 1 | 0.89 | 0.35 | |
| Relative diameter (surface area) | 1 | 2.3 | 0.8 | |
| Uptake normalized to surface area | 1 | 0.39 | 0.44 | |
| Cells per g liver | 1.5 × 107 | 1.15 × 108 | 4.8 × 107 | |
| mU/liver | 55 ± 13 | 385 ± 50 | 63 ± 46 | 503 ± 69 |
| % injected dose | 8.1 ± 1.8 | 56.5 ± 7.4 | 9.3 ± 6.8 | 73.9 ± 7.4 |
| % recovered dose | 11.4 ± 4.5 | 76.7 ± 5.4 | 11.8 ± 8.6 | 100 |