Recovery of Exogenous Glucocerebrosidase Activity in Different Liver Cell Types 20 Minutes After a Bolus IV Injection of rGCR to Balb/c Mice at a Dose of 40 U/kg Body Weight (approximately 680 mU/mouse)
| rGCR Measurement . | Liver Cell Type . | Total . | ||
|---|---|---|---|---|
| KC . | PC . | LEC/SC . | ||
| mU/106cells | 6.7 ± 1.6 | 2.9 ± 0.5 | 0.3 ± 0.6 | |
| Uptake normalized to 106 KC | 1 | 0.43 | 0.045 | |
| Relative diameter (surface area) | 1 | 2.3 | 0.8 | |
| Uptake normalized to surface area | 1 | 0.19 | 0.056 | |
| Cells per g liver | 1.5 × 107 | 1.15 × 108 | 4.8 × 107 | |
| mU/liver | 100 ± 23 | 338 ± 63 | 13 ± 30 | 451 ± 45 |
| % injected dose | 14.7 ± 3.4 | 49.7 ± 9.2 | 1.9 ± 4.4 | 66.3 ± 9.5 |
| % recovered dose | 23.0 ± 7.8 | 74.6 ± 5.2 | 2.4 ± 7.3 | 100 |
| rGCR Measurement . | Liver Cell Type . | Total . | ||
|---|---|---|---|---|
| KC . | PC . | LEC/SC . | ||
| mU/106cells | 6.7 ± 1.6 | 2.9 ± 0.5 | 0.3 ± 0.6 | |
| Uptake normalized to 106 KC | 1 | 0.43 | 0.045 | |
| Relative diameter (surface area) | 1 | 2.3 | 0.8 | |
| Uptake normalized to surface area | 1 | 0.19 | 0.056 | |
| Cells per g liver | 1.5 × 107 | 1.15 × 108 | 4.8 × 107 | |
| mU/liver | 100 ± 23 | 338 ± 63 | 13 ± 30 | 451 ± 45 |
| % injected dose | 14.7 ± 3.4 | 49.7 ± 9.2 | 1.9 ± 4.4 | 66.3 ± 9.5 |
| % recovered dose | 23.0 ± 7.8 | 74.6 ± 5.2 | 2.4 ± 7.3 | 100 |