Table 1. Morphological and... | American Society of Hematology

Table 1.

Morphological and Immunohistological Features of 96 T/null CD30⁺ Anaplastic Large-Cell Lymphoma

Type	No.	Morphological Variants	Pattern of ALK Positivity in Tumor Cells
ALK⁺	58	Common type (48/58)	29/58 all (c + n)^*
			10/58 many (c + n)^†, few (n)^‡
			9/58 all (c)^*
		Lymphohistiocytic (5/58)	5/5 few (c + n)^†, many (n)^‡
		Small cell (3/58)	3/3 few (c + n)^†, many (n)^‡
		Giant cell (2/58)	2/2 all (c)^*
ALK⁻	38	Common type (31/38)^1-153	—
		Giant cell (6/38)	—
		Signet ring (1/38)	—
Total	96

Type	No.	Morphological Variants	Pattern of ALK Positivity in Tumor Cells
ALK⁺	58	Common type (48/58)	29/58 all (c + n)^*
			10/58 many (c + n)^†, few (n)^‡
			9/58 all (c)^*
		Lymphohistiocytic (5/58)	5/5 few (c + n)^†, many (n)^‡
		Small cell (3/58)	3/3 few (c + n)^†, many (n)^‡
		Giant cell (2/58)	2/2 all (c)^*
ALK⁻	38	Common type (31/38)^1-153	—
		Giant cell (6/38)	—
		Signet ring (1/38)	—
Total	96

Abbreviations: c, cytoplasmic; n, nuclear.

Only large anaplastic cells (no small tumor cells were observed in these cases).

Mostly large anaplastic cells.

Mostly small cells.

Tumor cells were frequently more pleomorphic than in common type ALK⁺ lymphoma.